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Continuous Drug Release by Sea Anemone Nematostella vectensis Stinging Microcapsules

Transdermal delivery is an attractive option for drug delivery. Nevertheless, the skin is a tough barrier and only a limited number of drugs can be delivered through it. The most difficult to deliver are hydrophilic drugs. The stinging mechanism of the cnidarians is a sophisticated injection system...

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Autores principales: Tal, Yossi, Ayalon, Ari, Sharaev, Agnesa, Kazir, Zoya, Brekhman, Vera, Lotan, Tamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944512/
https://www.ncbi.nlm.nih.gov/pubmed/24473172
http://dx.doi.org/10.3390/md12020734
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author Tal, Yossi
Ayalon, Ari
Sharaev, Agnesa
Kazir, Zoya
Brekhman, Vera
Lotan, Tamar
author_facet Tal, Yossi
Ayalon, Ari
Sharaev, Agnesa
Kazir, Zoya
Brekhman, Vera
Lotan, Tamar
author_sort Tal, Yossi
collection PubMed
description Transdermal delivery is an attractive option for drug delivery. Nevertheless, the skin is a tough barrier and only a limited number of drugs can be delivered through it. The most difficult to deliver are hydrophilic drugs. The stinging mechanism of the cnidarians is a sophisticated injection system consisting of microcapsular nematocysts, which utilize built-in high osmotic pressures to inject a submicron tubule that penetrates and delivers their contents to the prey. Here we show, for the first time, that the nematocysts of the starlet sea anemone Nematostella vectensis can be isolated and incorporated into a topical formulation for continuous drug delivery. We demonstrate quantitative delivery of nicotinamide and lidocaine hydrochloride as a function of microcapsular dose or drug exposure. We also show how the released submicron tubules can be exploited as a skin penetration enhancer prior to and independently of drug application. The microcapsules are non-irritant and may offer an attractive alternative for hydrophilic transdermal drug delivery.
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spelling pubmed-39445122014-03-07 Continuous Drug Release by Sea Anemone Nematostella vectensis Stinging Microcapsules Tal, Yossi Ayalon, Ari Sharaev, Agnesa Kazir, Zoya Brekhman, Vera Lotan, Tamar Mar Drugs Transdermal delivery is an attractive option for drug delivery. Nevertheless, the skin is a tough barrier and only a limited number of drugs can be delivered through it. The most difficult to deliver are hydrophilic drugs. The stinging mechanism of the cnidarians is a sophisticated injection system consisting of microcapsular nematocysts, which utilize built-in high osmotic pressures to inject a submicron tubule that penetrates and delivers their contents to the prey. Here we show, for the first time, that the nematocysts of the starlet sea anemone Nematostella vectensis can be isolated and incorporated into a topical formulation for continuous drug delivery. We demonstrate quantitative delivery of nicotinamide and lidocaine hydrochloride as a function of microcapsular dose or drug exposure. We also show how the released submicron tubules can be exploited as a skin penetration enhancer prior to and independently of drug application. The microcapsules are non-irritant and may offer an attractive alternative for hydrophilic transdermal drug delivery. MDPI 2014-01-27 /pmc/articles/PMC3944512/ /pubmed/24473172 http://dx.doi.org/10.3390/md12020734 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Tal, Yossi
Ayalon, Ari
Sharaev, Agnesa
Kazir, Zoya
Brekhman, Vera
Lotan, Tamar
Continuous Drug Release by Sea Anemone Nematostella vectensis Stinging Microcapsules
title Continuous Drug Release by Sea Anemone Nematostella vectensis Stinging Microcapsules
title_full Continuous Drug Release by Sea Anemone Nematostella vectensis Stinging Microcapsules
title_fullStr Continuous Drug Release by Sea Anemone Nematostella vectensis Stinging Microcapsules
title_full_unstemmed Continuous Drug Release by Sea Anemone Nematostella vectensis Stinging Microcapsules
title_short Continuous Drug Release by Sea Anemone Nematostella vectensis Stinging Microcapsules
title_sort continuous drug release by sea anemone nematostella vectensis stinging microcapsules
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944512/
https://www.ncbi.nlm.nih.gov/pubmed/24473172
http://dx.doi.org/10.3390/md12020734
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