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Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule
New cembranoids, sarcocrassocolides P–R (1–3) and four known compounds (4–7) were isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 3–5 and 7 were shown to exhibit cytotoxicity toward a limited panel...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944518/ https://www.ncbi.nlm.nih.gov/pubmed/24477285 http://dx.doi.org/10.3390/md12020840 |
| _version_ | 1782306394847838208 |
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| author | Lin, Wan-Yu Chen, Bo-Wei Huang, Chiung-Yao Wen, Zhi-Hong Sung, Ping-Jyun Su, Jui-Hsin Dai, Chang-Feng Sheu, Jyh-Horng |
| author_facet | Lin, Wan-Yu Chen, Bo-Wei Huang, Chiung-Yao Wen, Zhi-Hong Sung, Ping-Jyun Su, Jui-Hsin Dai, Chang-Feng Sheu, Jyh-Horng |
| author_sort | Lin, Wan-Yu |
| collection | PubMed |
| description | New cembranoids, sarcocrassocolides P–R (1–3) and four known compounds (4–7) were isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 3–5 and 7 were shown to exhibit cytotoxicity toward a limited panel of cancer cell lines and all compounds 1–7 displayed potent in vitro anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells by inhibiting the expression of inducible nitric oxide synthase (iNOS) protein. Compound 7 also showed significant activity in reducing the accumulation of cyclooxygenase-2 (COX-2) protein in the same macrophage cells. |
| format | Online Article Text |
| id | pubmed-3944518 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-39445182014-03-07 Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule Lin, Wan-Yu Chen, Bo-Wei Huang, Chiung-Yao Wen, Zhi-Hong Sung, Ping-Jyun Su, Jui-Hsin Dai, Chang-Feng Sheu, Jyh-Horng Mar Drugs New cembranoids, sarcocrassocolides P–R (1–3) and four known compounds (4–7) were isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 3–5 and 7 were shown to exhibit cytotoxicity toward a limited panel of cancer cell lines and all compounds 1–7 displayed potent in vitro anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells by inhibiting the expression of inducible nitric oxide synthase (iNOS) protein. Compound 7 also showed significant activity in reducing the accumulation of cyclooxygenase-2 (COX-2) protein in the same macrophage cells. MDPI 2014-01-28 /pmc/articles/PMC3944518/ /pubmed/24477285 http://dx.doi.org/10.3390/md12020840 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| spellingShingle | Lin, Wan-Yu Chen, Bo-Wei Huang, Chiung-Yao Wen, Zhi-Hong Sung, Ping-Jyun Su, Jui-Hsin Dai, Chang-Feng Sheu, Jyh-Horng Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule |
| title | Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule |
| title_full | Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule |
| title_fullStr | Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule |
| title_full_unstemmed | Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule |
| title_short | Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule |
| title_sort | bioactive cembranoids, sarcocrassocolides p–r, from the dongsha atoll soft coral sarcophyton crassocaule |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944518/ https://www.ncbi.nlm.nih.gov/pubmed/24477285 http://dx.doi.org/10.3390/md12020840 |
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