Synthesis of PPAR-γ Activators Inspired by the Marine Natural Product, Paecilocin A

A series of N-substituted phthalimide derivatives were synthesized based on a pharmacophore study of paecilocin A (a natural PPAR-γ agonist) and synthetic leads. The introduction of hydrophilic and hydrophobic groups to the phthalimide skeleton yielded compounds 3–14. Compound 7 showed significant P...

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Detalles Bibliográficos
Autores principales: Xiao, Bin, Su, Mingzhi, Kim, Eun La, Hong, Jongki, Chung, Hae Young, Kim, Hyung Sik, Yin, Jun, Jung, Jee H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944523/
https://www.ncbi.nlm.nih.gov/pubmed/24531188
http://dx.doi.org/10.3390/md12020926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944523/
https://www.ncbi.nlm.nih.gov/pubmed/24531188
http://dx.doi.org/10.3390/md12020926

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