Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310

A new actinomycete strain Micromonospora sp. K310 was isolated from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of two new compounds from the fermentation culture. One of the compounds is butremycin (2) which is the (3-hydroxyl) derivative of the known St...

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Autores principales: Kyeremeh, Kwaku, Sekyi Acquah, Kojo, Sazak, Anil, Houssen, Wael, Tabudravu, Jioji, Deng, Hai, Jaspars, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944527/
https://www.ncbi.nlm.nih.gov/pubmed/24534843
http://dx.doi.org/10.3390/md12020999
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author Kyeremeh, Kwaku
Sekyi Acquah, Kojo
Sazak, Anil
Houssen, Wael
Tabudravu, Jioji
Deng, Hai
Jaspars, Marcel
author_facet Kyeremeh, Kwaku
Sekyi Acquah, Kojo
Sazak, Anil
Houssen, Wael
Tabudravu, Jioji
Deng, Hai
Jaspars, Marcel
author_sort Kyeremeh, Kwaku
collection PubMed
description A new actinomycete strain Micromonospora sp. K310 was isolated from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of two new compounds from the fermentation culture. One of the compounds is butremycin (2) which is the (3-hydroxyl) derivative of the known Streptomyces metabolite ikarugamycin (1) and the other compound is a protonated aromatic tautomer of 5′-methylthioinosine (MTI) (3). Both new compounds were characterized by 1D, 2D NMR and MS data. Butremycin (2) displayed weak antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains while 3 did not show any antibacterial activity against these microbes.
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spelling pubmed-39445272014-03-07 Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310 Kyeremeh, Kwaku Sekyi Acquah, Kojo Sazak, Anil Houssen, Wael Tabudravu, Jioji Deng, Hai Jaspars, Marcel Mar Drugs A new actinomycete strain Micromonospora sp. K310 was isolated from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of two new compounds from the fermentation culture. One of the compounds is butremycin (2) which is the (3-hydroxyl) derivative of the known Streptomyces metabolite ikarugamycin (1) and the other compound is a protonated aromatic tautomer of 5′-methylthioinosine (MTI) (3). Both new compounds were characterized by 1D, 2D NMR and MS data. Butremycin (2) displayed weak antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains while 3 did not show any antibacterial activity against these microbes. MDPI 2014-02-14 /pmc/articles/PMC3944527/ /pubmed/24534843 http://dx.doi.org/10.3390/md12020999 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Kyeremeh, Kwaku
Sekyi Acquah, Kojo
Sazak, Anil
Houssen, Wael
Tabudravu, Jioji
Deng, Hai
Jaspars, Marcel
Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310
title Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310
title_full Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310
title_fullStr Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310
title_full_unstemmed Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310
title_short Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310
title_sort butremycin, the 3-hydroxyl derivative of ikarugamycin and a protonated aromatic tautomer of 5′-methylthioinosine from a ghanaian micromonospora sp. k310
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944527/
https://www.ncbi.nlm.nih.gov/pubmed/24534843
http://dx.doi.org/10.3390/md12020999
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