Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.

Two novel trialkyl-substituted aromatic acids, solwaric acids A and B, were isolated from a marine Solwaraspora sp. cultivated from the ascidian Trididemnum orbiculatum. Solwaric acids A and B were isotopically labeled with U-(13)C glucose, and analysis of a (13)C–(13)C COSY allowed for unambiguous...

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Detalles Bibliográficos
Autores principales: Ellis, Gregory A., Wyche, Thomas P., Fry, Charles G., Braun, Doug R., Bugni, Tim S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944528/
https://www.ncbi.nlm.nih.gov/pubmed/24534844
http://dx.doi.org/10.3390/md12021013
Descripción
Sumario:Two novel trialkyl-substituted aromatic acids, solwaric acids A and B, were isolated from a marine Solwaraspora sp. cultivated from the ascidian Trididemnum orbiculatum. Solwaric acids A and B were isotopically labeled with U-(13)C glucose, and analysis of a (13)C–(13)C COSY allowed for unambiguous determination of the location of the phenyl methyl group. The two novel compounds demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA).

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