Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.

Two novel trialkyl-substituted aromatic acids, solwaric acids A and B, were isolated from a marine Solwaraspora sp. cultivated from the ascidian Trididemnum orbiculatum. Solwaric acids A and B were isotopically labeled with U-(13)C glucose, and analysis of a (13)C–(13)C COSY allowed for unambiguous...

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Autores principales: Ellis, Gregory A., Wyche, Thomas P., Fry, Charles G., Braun, Doug R., Bugni, Tim S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944528/
https://www.ncbi.nlm.nih.gov/pubmed/24534844
http://dx.doi.org/10.3390/md12021013
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author Ellis, Gregory A.
Wyche, Thomas P.
Fry, Charles G.
Braun, Doug R.
Bugni, Tim S.
author_facet Ellis, Gregory A.
Wyche, Thomas P.
Fry, Charles G.
Braun, Doug R.
Bugni, Tim S.
author_sort Ellis, Gregory A.
collection PubMed
description Two novel trialkyl-substituted aromatic acids, solwaric acids A and B, were isolated from a marine Solwaraspora sp. cultivated from the ascidian Trididemnum orbiculatum. Solwaric acids A and B were isotopically labeled with U-(13)C glucose, and analysis of a (13)C–(13)C COSY allowed for unambiguous determination of the location of the phenyl methyl group. The two novel compounds demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA).
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spelling pubmed-39445282014-03-07 Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp. Ellis, Gregory A. Wyche, Thomas P. Fry, Charles G. Braun, Doug R. Bugni, Tim S. Mar Drugs Two novel trialkyl-substituted aromatic acids, solwaric acids A and B, were isolated from a marine Solwaraspora sp. cultivated from the ascidian Trididemnum orbiculatum. Solwaric acids A and B were isotopically labeled with U-(13)C glucose, and analysis of a (13)C–(13)C COSY allowed for unambiguous determination of the location of the phenyl methyl group. The two novel compounds demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA). MDPI 2014-02-14 /pmc/articles/PMC3944528/ /pubmed/24534844 http://dx.doi.org/10.3390/md12021013 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Ellis, Gregory A.
Wyche, Thomas P.
Fry, Charles G.
Braun, Doug R.
Bugni, Tim S.
Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.
title Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.
title_full Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.
title_fullStr Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.
title_full_unstemmed Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.
title_short Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.
title_sort solwaric acids a and b, antibacterial aromatic acids from a marine solwaraspora sp.
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944528/
https://www.ncbi.nlm.nih.gov/pubmed/24534844
http://dx.doi.org/10.3390/md12021013
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