Krempfielins N–P, New Anti-Inflammatory Eunicellins from a Taiwanese Soft Coral Cladiella krempfi

Three new eunicellin-type diterpenoids, krempfielins N–P (1–3), were isolated from a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compound 3 exhi...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Yan-Ning, Tai, Chi-Jen, Hwang, Tsong-Long, Sheu, Jyh-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944535/
https://www.ncbi.nlm.nih.gov/pubmed/24566263
http://dx.doi.org/10.3390/md12021148
_version_ 1782306398746443776
author Lee, Yan-Ning
Tai, Chi-Jen
Hwang, Tsong-Long
Sheu, Jyh-Horng
author_facet Lee, Yan-Ning
Tai, Chi-Jen
Hwang, Tsong-Long
Sheu, Jyh-Horng
author_sort Lee, Yan-Ning
collection PubMed
description Three new eunicellin-type diterpenoids, krempfielins N–P (1–3), were isolated from a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compound 3 exhibited activity to inhibit superoxide anion generation. Both 1 and3, in particular 1, were shown to display significant anti-inflammatory activity by inhibiting the elastase release in FMLP/CB-induced human neutrophils.
format Online
Article
Text
id pubmed-3944535
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-39445352014-03-07 Krempfielins N–P, New Anti-Inflammatory Eunicellins from a Taiwanese Soft Coral Cladiella krempfi Lee, Yan-Ning Tai, Chi-Jen Hwang, Tsong-Long Sheu, Jyh-Horng Mar Drugs Three new eunicellin-type diterpenoids, krempfielins N–P (1–3), were isolated from a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compound 3 exhibited activity to inhibit superoxide anion generation. Both 1 and3, in particular 1, were shown to display significant anti-inflammatory activity by inhibiting the elastase release in FMLP/CB-induced human neutrophils. MDPI 2014-02-21 /pmc/articles/PMC3944535/ /pubmed/24566263 http://dx.doi.org/10.3390/md12021148 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Lee, Yan-Ning
Tai, Chi-Jen
Hwang, Tsong-Long
Sheu, Jyh-Horng
Krempfielins N–P, New Anti-Inflammatory Eunicellins from a Taiwanese Soft Coral Cladiella krempfi
title Krempfielins N–P, New Anti-Inflammatory Eunicellins from a Taiwanese Soft Coral Cladiella krempfi
title_full Krempfielins N–P, New Anti-Inflammatory Eunicellins from a Taiwanese Soft Coral Cladiella krempfi
title_fullStr Krempfielins N–P, New Anti-Inflammatory Eunicellins from a Taiwanese Soft Coral Cladiella krempfi
title_full_unstemmed Krempfielins N–P, New Anti-Inflammatory Eunicellins from a Taiwanese Soft Coral Cladiella krempfi
title_short Krempfielins N–P, New Anti-Inflammatory Eunicellins from a Taiwanese Soft Coral Cladiella krempfi
title_sort krempfielins n–p, new anti-inflammatory eunicellins from a taiwanese soft coral cladiella krempfi
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944535/
https://www.ncbi.nlm.nih.gov/pubmed/24566263
http://dx.doi.org/10.3390/md12021148
work_keys_str_mv AT leeyanning krempfielinsnpnewantiinflammatoryeunicellinsfromataiwanesesoftcoralcladiellakrempfi
AT taichijen krempfielinsnpnewantiinflammatoryeunicellinsfromataiwanesesoftcoralcladiellakrempfi
AT hwangtsonglong krempfielinsnpnewantiinflammatoryeunicellinsfromataiwanesesoftcoralcladiellakrempfi
AT sheujyhhorng krempfielinsnpnewantiinflammatoryeunicellinsfromataiwanesesoftcoralcladiellakrempfi

Ejemplares similares