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INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION

The purpose of this study was to examine the effect of acute low-dose celecoxib administration on exercise-induced inflammation, muscle damage and lipid peroxidation. Twenty healthy untrained males (age: 25.5±4.5 yrs, weight: 72.7±7.9 kg, height: 177.3±7.2 cm) were randomly assigned to treatment (T)...

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Autores principales: Khoshkhahesh, F., Siahkuhain, M., Fisher, G., Nakhostin-Roohi, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Institute of Sport in Warsaw 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944556/
https://www.ncbi.nlm.nih.gov/pubmed/24744468
http://dx.doi.org/10.5604/20831862.1029824
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author Khoshkhahesh, F.
Siahkuhain, M.
Fisher, G.
Nakhostin-Roohi, B.
author_facet Khoshkhahesh, F.
Siahkuhain, M.
Fisher, G.
Nakhostin-Roohi, B.
author_sort Khoshkhahesh, F.
collection PubMed
description The purpose of this study was to examine the effect of acute low-dose celecoxib administration on exercise-induced inflammation, muscle damage and lipid peroxidation. Twenty healthy untrained males (age: 25.5±4.5 yrs, weight: 72.7±7.9 kg, height: 177.3±7.2 cm) were randomly assigned to treatment (T) or placebo (P) groups. Blood samples were obtained before, immediately after, 3 h after and 24 h after exercise. Subjects ran for 30 min at 75% [Formula: see text] O(2) max on a treadmill. Participants consumed 100 mg celecoxib or a placebo immediately after and 12 h after the immediately post-exercise blood sample. Total leukocytes, neutrophils, creatine kinase (CK), C-reactive protein (CRP) and malondialdehyde (MDA) were assessed at each time point. Significant increases in total leukocytes and neutrophils were observed 3 h after exercise in both groups (P < 0.05). CK and CRP levels were significantly increased immediately, 3 h and 24 h after exercise in both groups (P < 0.05). A significant increase in MDA was observed immediately after exercise in both groups (P < 0.05); however, no significant group differences were observed for MDA or CK. These findings suggest that inhibition of cyclo-oxygenase activity with low-dose celecoxib does not affect exercise-induced inflammation, muscle damage, or lipid peroxidation.
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spelling pubmed-39445562014-04-17 INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION Khoshkhahesh, F. Siahkuhain, M. Fisher, G. Nakhostin-Roohi, B. Biol Sport Original Paper The purpose of this study was to examine the effect of acute low-dose celecoxib administration on exercise-induced inflammation, muscle damage and lipid peroxidation. Twenty healthy untrained males (age: 25.5±4.5 yrs, weight: 72.7±7.9 kg, height: 177.3±7.2 cm) were randomly assigned to treatment (T) or placebo (P) groups. Blood samples were obtained before, immediately after, 3 h after and 24 h after exercise. Subjects ran for 30 min at 75% [Formula: see text] O(2) max on a treadmill. Participants consumed 100 mg celecoxib or a placebo immediately after and 12 h after the immediately post-exercise blood sample. Total leukocytes, neutrophils, creatine kinase (CK), C-reactive protein (CRP) and malondialdehyde (MDA) were assessed at each time point. Significant increases in total leukocytes and neutrophils were observed 3 h after exercise in both groups (P < 0.05). CK and CRP levels were significantly increased immediately, 3 h and 24 h after exercise in both groups (P < 0.05). A significant increase in MDA was observed immediately after exercise in both groups (P < 0.05); however, no significant group differences were observed for MDA or CK. These findings suggest that inhibition of cyclo-oxygenase activity with low-dose celecoxib does not affect exercise-induced inflammation, muscle damage, or lipid peroxidation. Institute of Sport in Warsaw 2013-01-21 2013-03 /pmc/articles/PMC3944556/ /pubmed/24744468 http://dx.doi.org/10.5604/20831862.1029824 Text en Copyright © Biology of Sport 2013 http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Khoshkhahesh, F.
Siahkuhain, M.
Fisher, G.
Nakhostin-Roohi, B.
INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION
title INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION
title_full INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION
title_fullStr INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION
title_full_unstemmed INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION
title_short INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION
title_sort influence of a low-dose cox-2 inhibitor drug on exercise-induced inflammation, muscle damage and lipid peroxidation
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944556/
https://www.ncbi.nlm.nih.gov/pubmed/24744468
http://dx.doi.org/10.5604/20831862.1029824
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