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INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION
The purpose of this study was to examine the effect of acute low-dose celecoxib administration on exercise-induced inflammation, muscle damage and lipid peroxidation. Twenty healthy untrained males (age: 25.5±4.5 yrs, weight: 72.7±7.9 kg, height: 177.3±7.2 cm) were randomly assigned to treatment (T)...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Institute of Sport in Warsaw
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944556/ https://www.ncbi.nlm.nih.gov/pubmed/24744468 http://dx.doi.org/10.5604/20831862.1029824 |
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author | Khoshkhahesh, F. Siahkuhain, M. Fisher, G. Nakhostin-Roohi, B. |
author_facet | Khoshkhahesh, F. Siahkuhain, M. Fisher, G. Nakhostin-Roohi, B. |
author_sort | Khoshkhahesh, F. |
collection | PubMed |
description | The purpose of this study was to examine the effect of acute low-dose celecoxib administration on exercise-induced inflammation, muscle damage and lipid peroxidation. Twenty healthy untrained males (age: 25.5±4.5 yrs, weight: 72.7±7.9 kg, height: 177.3±7.2 cm) were randomly assigned to treatment (T) or placebo (P) groups. Blood samples were obtained before, immediately after, 3 h after and 24 h after exercise. Subjects ran for 30 min at 75% [Formula: see text] O(2) max on a treadmill. Participants consumed 100 mg celecoxib or a placebo immediately after and 12 h after the immediately post-exercise blood sample. Total leukocytes, neutrophils, creatine kinase (CK), C-reactive protein (CRP) and malondialdehyde (MDA) were assessed at each time point. Significant increases in total leukocytes and neutrophils were observed 3 h after exercise in both groups (P < 0.05). CK and CRP levels were significantly increased immediately, 3 h and 24 h after exercise in both groups (P < 0.05). A significant increase in MDA was observed immediately after exercise in both groups (P < 0.05); however, no significant group differences were observed for MDA or CK. These findings suggest that inhibition of cyclo-oxygenase activity with low-dose celecoxib does not affect exercise-induced inflammation, muscle damage, or lipid peroxidation. |
format | Online Article Text |
id | pubmed-3944556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Institute of Sport in Warsaw |
record_format | MEDLINE/PubMed |
spelling | pubmed-39445562014-04-17 INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION Khoshkhahesh, F. Siahkuhain, M. Fisher, G. Nakhostin-Roohi, B. Biol Sport Original Paper The purpose of this study was to examine the effect of acute low-dose celecoxib administration on exercise-induced inflammation, muscle damage and lipid peroxidation. Twenty healthy untrained males (age: 25.5±4.5 yrs, weight: 72.7±7.9 kg, height: 177.3±7.2 cm) were randomly assigned to treatment (T) or placebo (P) groups. Blood samples were obtained before, immediately after, 3 h after and 24 h after exercise. Subjects ran for 30 min at 75% [Formula: see text] O(2) max on a treadmill. Participants consumed 100 mg celecoxib or a placebo immediately after and 12 h after the immediately post-exercise blood sample. Total leukocytes, neutrophils, creatine kinase (CK), C-reactive protein (CRP) and malondialdehyde (MDA) were assessed at each time point. Significant increases in total leukocytes and neutrophils were observed 3 h after exercise in both groups (P < 0.05). CK and CRP levels were significantly increased immediately, 3 h and 24 h after exercise in both groups (P < 0.05). A significant increase in MDA was observed immediately after exercise in both groups (P < 0.05); however, no significant group differences were observed for MDA or CK. These findings suggest that inhibition of cyclo-oxygenase activity with low-dose celecoxib does not affect exercise-induced inflammation, muscle damage, or lipid peroxidation. Institute of Sport in Warsaw 2013-01-21 2013-03 /pmc/articles/PMC3944556/ /pubmed/24744468 http://dx.doi.org/10.5604/20831862.1029824 Text en Copyright © Biology of Sport 2013 http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Khoshkhahesh, F. Siahkuhain, M. Fisher, G. Nakhostin-Roohi, B. INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION |
title | INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION |
title_full | INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION |
title_fullStr | INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION |
title_full_unstemmed | INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION |
title_short | INFLUENCE OF A LOW-DOSE COX-2 INHIBITOR DRUG ON EXERCISE-INDUCED INFLAMMATION, MUSCLE DAMAGE AND LIPID PEROXIDATION |
title_sort | influence of a low-dose cox-2 inhibitor drug on exercise-induced inflammation, muscle damage and lipid peroxidation |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944556/ https://www.ncbi.nlm.nih.gov/pubmed/24744468 http://dx.doi.org/10.5604/20831862.1029824 |
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