Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene

To follow-up loci discovered by the International Genomics of Alzheimer's Disease Project, we attempted independent replication of 19 single nucleotide polymorphisms (SNPs) in a large Spanish sample (Fundació ACE data set; 1808 patients and 2564 controls). Our results corroborate association wi...

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Autores principales: Ruiz, A, Heilmann, S, Becker, T, Hernández, I, Wagner, H, Thelen, M, Mauleón, A, Rosende-Roca, M, Bellenguez, C, Bis, J C, Harold, D, Gerrish, A, Sims, R, Sotolongo-Grau, O, Espinosa, A, Alegret, M, Arrieta, J L, Lacour, A, Leber, M, Becker, J, Lafuente, A, Ruiz, S, Vargas, L, Rodríguez, O, Ortega, G, Dominguez, M-A, Mayeux, R, Haines, J L, Pericak-Vance, M A, Farrer, L A, Schellenberg, G D, Chouraki, V, Launer, L J, van Duijn, C, Seshadri, S, Antúnez, C, Breteler, M M, Serrano-Ríos, M, Jessen, F, Tárraga, L, Nöthen, M M, Maier, W, Boada, M, Ramírez, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944635/
https://www.ncbi.nlm.nih.gov/pubmed/24495969
http://dx.doi.org/10.1038/tp.2014.2
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author Ruiz, A
Heilmann, S
Becker, T
Hernández, I
Wagner, H
Thelen, M
Mauleón, A
Rosende-Roca, M
Bellenguez, C
Bis, J C
Harold, D
Gerrish, A
Sims, R
Sotolongo-Grau, O
Espinosa, A
Alegret, M
Arrieta, J L
Lacour, A
Leber, M
Becker, J
Lafuente, A
Ruiz, S
Vargas, L
Rodríguez, O
Ortega, G
Dominguez, M-A
Mayeux, R
Haines, J L
Pericak-Vance, M A
Farrer, L A
Schellenberg, G D
Chouraki, V
Launer, L J
van Duijn, C
Seshadri, S
Antúnez, C
Breteler, M M
Serrano-Ríos, M
Jessen, F
Tárraga, L
Nöthen, M M
Maier, W
Boada, M
Ramírez, A
author_facet Ruiz, A
Heilmann, S
Becker, T
Hernández, I
Wagner, H
Thelen, M
Mauleón, A
Rosende-Roca, M
Bellenguez, C
Bis, J C
Harold, D
Gerrish, A
Sims, R
Sotolongo-Grau, O
Espinosa, A
Alegret, M
Arrieta, J L
Lacour, A
Leber, M
Becker, J
Lafuente, A
Ruiz, S
Vargas, L
Rodríguez, O
Ortega, G
Dominguez, M-A
Mayeux, R
Haines, J L
Pericak-Vance, M A
Farrer, L A
Schellenberg, G D
Chouraki, V
Launer, L J
van Duijn, C
Seshadri, S
Antúnez, C
Breteler, M M
Serrano-Ríos, M
Jessen, F
Tárraga, L
Nöthen, M M
Maier, W
Boada, M
Ramírez, A
author_sort Ruiz, A
collection PubMed
description To follow-up loci discovered by the International Genomics of Alzheimer's Disease Project, we attempted independent replication of 19 single nucleotide polymorphisms (SNPs) in a large Spanish sample (Fundació ACE data set; 1808 patients and 2564 controls). Our results corroborate association with four SNPs located in the genes INPP5D, MEF2C, ZCWPW1 and FERMT2, respectively. Of these, ZCWPW1 was the only SNP to withstand correction for multiple testing (P=0.000655). Furthermore, we identify TRIP4 (rs74615166) as a novel genome-wide significant locus for Alzheimer's disease risk (odds ratio=1.31; confidence interval 95% (1.19–1.44); P=9.74 × 10(−)(9)).
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spelling pubmed-39446352014-03-06 Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene Ruiz, A Heilmann, S Becker, T Hernández, I Wagner, H Thelen, M Mauleón, A Rosende-Roca, M Bellenguez, C Bis, J C Harold, D Gerrish, A Sims, R Sotolongo-Grau, O Espinosa, A Alegret, M Arrieta, J L Lacour, A Leber, M Becker, J Lafuente, A Ruiz, S Vargas, L Rodríguez, O Ortega, G Dominguez, M-A Mayeux, R Haines, J L Pericak-Vance, M A Farrer, L A Schellenberg, G D Chouraki, V Launer, L J van Duijn, C Seshadri, S Antúnez, C Breteler, M M Serrano-Ríos, M Jessen, F Tárraga, L Nöthen, M M Maier, W Boada, M Ramírez, A Transl Psychiatry Original Article To follow-up loci discovered by the International Genomics of Alzheimer's Disease Project, we attempted independent replication of 19 single nucleotide polymorphisms (SNPs) in a large Spanish sample (Fundació ACE data set; 1808 patients and 2564 controls). Our results corroborate association with four SNPs located in the genes INPP5D, MEF2C, ZCWPW1 and FERMT2, respectively. Of these, ZCWPW1 was the only SNP to withstand correction for multiple testing (P=0.000655). Furthermore, we identify TRIP4 (rs74615166) as a novel genome-wide significant locus for Alzheimer's disease risk (odds ratio=1.31; confidence interval 95% (1.19–1.44); P=9.74 × 10(−)(9)). Nature Publishing Group 2014-02 2014-02-04 /pmc/articles/PMC3944635/ /pubmed/24495969 http://dx.doi.org/10.1038/tp.2014.2 Text en Copyright © 2014 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Original Article
Ruiz, A
Heilmann, S
Becker, T
Hernández, I
Wagner, H
Thelen, M
Mauleón, A
Rosende-Roca, M
Bellenguez, C
Bis, J C
Harold, D
Gerrish, A
Sims, R
Sotolongo-Grau, O
Espinosa, A
Alegret, M
Arrieta, J L
Lacour, A
Leber, M
Becker, J
Lafuente, A
Ruiz, S
Vargas, L
Rodríguez, O
Ortega, G
Dominguez, M-A
Mayeux, R
Haines, J L
Pericak-Vance, M A
Farrer, L A
Schellenberg, G D
Chouraki, V
Launer, L J
van Duijn, C
Seshadri, S
Antúnez, C
Breteler, M M
Serrano-Ríos, M
Jessen, F
Tárraga, L
Nöthen, M M
Maier, W
Boada, M
Ramírez, A
Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene
title Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene
title_full Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene
title_fullStr Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene
title_full_unstemmed Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene
title_short Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene
title_sort follow-up of loci from the international genomics of alzheimer's disease project identifies trip4 as a novel susceptibility gene
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944635/
https://www.ncbi.nlm.nih.gov/pubmed/24495969
http://dx.doi.org/10.1038/tp.2014.2
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