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Pharmacological activation of NQO1 increases NAD(+) levels and attenuates cisplatin-mediated acute kidney injury in mice

Cisplatin is a widely used chemotherapeutic agent for the treatment of various tumors. In addition to its antitumor activity, cisplatin affects normal cells and may induce adverse effects, such as ototoxicity, nephrotoxicity, and neuropathy. Various mechanisms, such as DNA adduct formation, mitochon...

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Detalles Bibliográficos
Autores principales:	Oh, Gi-Su, Kim, Hyung-Jin, Choi, Jae-Hyuck, Shen, AiHua, Choe, Seong-Kyu, Karna, Anzani, Lee, Seung Hoon, Jo, Hyang-Jeong, Yang, Sei-Hoon, Kwak, Tae Hwan, Lee, Chul-Ho, Park, Raekil, So, Hong-Seob
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Basic Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944666/ https://www.ncbi.nlm.nih.gov/pubmed/24025646 http://dx.doi.org/10.1038/ki.2013.330

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