Cargando…
A range of C∊3–C∊4 interdomain angles in IgE Fc accommodate binding to its receptor CD23
The antibody IgE plays a central role in allergic disease, functioning principally through two cell-surface receptors: Fc∊RI and CD23. Fc∊RI on mast cells and basophils mediates the immediate hypersensitivity response, whilst the interaction of IgE with CD23 on B cells regulates IgE production. Crys...
Autores principales: | Dhaliwal, Balvinder, Pang, Marie O. Y., Yuan, Daopeng, Beavil, Andrew J., Sutton, Brian J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944690/ https://www.ncbi.nlm.nih.gov/pubmed/24598915 http://dx.doi.org/10.1107/S2053230X14003355 |
Ejemplares similares
-
Conformational plasticity at the IgE-binding site of the B-cell receptor CD23()
por: Dhaliwal, Balvinder, et al.
Publicado: (2013) -
IgE binds asymmetrically to its B cell receptor CD23
por: Dhaliwal, Balvinder, et al.
Publicado: (2017) -
Mapping of the CD23 Binding Site on Immunoglobulin E (IgE) and Allosteric Control of the IgE-FcϵRI Interaction
por: Borthakur, Susmita, et al.
Publicado: (2012) -
Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization
por: Mitropoulou, Alkistis N., et al.
Publicado: (2020) -
The structure of human CD23 and its interactions with IgE and CD21
por: Hibbert, Richard G., et al.
Publicado: (2005)