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Increased EMRSA-15 health-care worker colonization demonstrated in retrospective review of EMRSA hospital outbreaks

BACKGROUND: Health care worker (HCW) colonization with methicillin resistant Staphylococcus aureus (MRSA) is a documented cause of hospital outbreaks and contributes to ongoing transmission. At Royal Perth Hospital (RPH) it had been anecdotally noted that the increasing prevalence of EMRSA-15 appear...

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Autores principales: Hart, Julie, Christiansen, Keryn J, Lee, Rosie, Heath, Christopher H, Coombs, Geoffrey W, Robinson, J Owen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944736/
https://www.ncbi.nlm.nih.gov/pubmed/24588849
http://dx.doi.org/10.1186/2047-2994-3-7
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author Hart, Julie
Christiansen, Keryn J
Lee, Rosie
Heath, Christopher H
Coombs, Geoffrey W
Robinson, J Owen
author_facet Hart, Julie
Christiansen, Keryn J
Lee, Rosie
Heath, Christopher H
Coombs, Geoffrey W
Robinson, J Owen
author_sort Hart, Julie
collection PubMed
description BACKGROUND: Health care worker (HCW) colonization with methicillin resistant Staphylococcus aureus (MRSA) is a documented cause of hospital outbreaks and contributes to ongoing transmission. At Royal Perth Hospital (RPH) it had been anecdotally noted that the increasing prevalence of EMRSA-15 appeared to be associated with increased HCW colonization compared with Aus2/3-EMRSA. Hence we compared HCW colonization rates during outbreaks of EMRSA-15 and Aus2/3-EMRSA at a single institution. METHODS: We performed a retrospective review of EMRSA-15 and Aus2/3-EMRSA outbreaks from 2000–2009 at RPH, a quaternary hospital in Western Australia. Outbreak files were reviewed and relevant data extracted. RESULTS: Ten EMRSA-15 outbreaks were compared with seven Aus2/3 outbreaks. The number of patients colonized was similar between EMRSA-15 and Aus2/3-EMRSA outbreaks (median 7 [range 3–20] and 11 [5–26], respectively; P = 0.07) but the number of HCWs colonized was significantly higher in EMRSA-15 outbreaks compared to Aus2/3-EMRSA outbreaks (median 4 [range 0–15] and 2 [1-3], respectively; P = 0.013). The percentage of HCWs colonized was also higher in EMRSA-15 outbreaks versus Aus2/3-EMRSA outbreaks (median 3.4% [range 0–5.5%] and 0.81% [0.56–2.2%], respectively; P = 0.013). CONCLUSIONS: This study demonstrates a higher level of HCW colonization during EMRSA-15 outbreaks compared with Aus2/3-EMRSA outbreaks. This finding suggests that MRSA vary in their ability to colonize HCWs and contribute to outbreaks. MRSA type should be determined during outbreaks and future research should investigate the mechanisms by which EMRSA-15 contributes to increased HCW colonization.
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spelling pubmed-39447362014-03-07 Increased EMRSA-15 health-care worker colonization demonstrated in retrospective review of EMRSA hospital outbreaks Hart, Julie Christiansen, Keryn J Lee, Rosie Heath, Christopher H Coombs, Geoffrey W Robinson, J Owen Antimicrob Resist Infect Control Research BACKGROUND: Health care worker (HCW) colonization with methicillin resistant Staphylococcus aureus (MRSA) is a documented cause of hospital outbreaks and contributes to ongoing transmission. At Royal Perth Hospital (RPH) it had been anecdotally noted that the increasing prevalence of EMRSA-15 appeared to be associated with increased HCW colonization compared with Aus2/3-EMRSA. Hence we compared HCW colonization rates during outbreaks of EMRSA-15 and Aus2/3-EMRSA at a single institution. METHODS: We performed a retrospective review of EMRSA-15 and Aus2/3-EMRSA outbreaks from 2000–2009 at RPH, a quaternary hospital in Western Australia. Outbreak files were reviewed and relevant data extracted. RESULTS: Ten EMRSA-15 outbreaks were compared with seven Aus2/3 outbreaks. The number of patients colonized was similar between EMRSA-15 and Aus2/3-EMRSA outbreaks (median 7 [range 3–20] and 11 [5–26], respectively; P = 0.07) but the number of HCWs colonized was significantly higher in EMRSA-15 outbreaks compared to Aus2/3-EMRSA outbreaks (median 4 [range 0–15] and 2 [1-3], respectively; P = 0.013). The percentage of HCWs colonized was also higher in EMRSA-15 outbreaks versus Aus2/3-EMRSA outbreaks (median 3.4% [range 0–5.5%] and 0.81% [0.56–2.2%], respectively; P = 0.013). CONCLUSIONS: This study demonstrates a higher level of HCW colonization during EMRSA-15 outbreaks compared with Aus2/3-EMRSA outbreaks. This finding suggests that MRSA vary in their ability to colonize HCWs and contribute to outbreaks. MRSA type should be determined during outbreaks and future research should investigate the mechanisms by which EMRSA-15 contributes to increased HCW colonization. BioMed Central 2014-03-03 /pmc/articles/PMC3944736/ /pubmed/24588849 http://dx.doi.org/10.1186/2047-2994-3-7 Text en Copyright © 2014 Hart et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Hart, Julie
Christiansen, Keryn J
Lee, Rosie
Heath, Christopher H
Coombs, Geoffrey W
Robinson, J Owen
Increased EMRSA-15 health-care worker colonization demonstrated in retrospective review of EMRSA hospital outbreaks
title Increased EMRSA-15 health-care worker colonization demonstrated in retrospective review of EMRSA hospital outbreaks
title_full Increased EMRSA-15 health-care worker colonization demonstrated in retrospective review of EMRSA hospital outbreaks
title_fullStr Increased EMRSA-15 health-care worker colonization demonstrated in retrospective review of EMRSA hospital outbreaks
title_full_unstemmed Increased EMRSA-15 health-care worker colonization demonstrated in retrospective review of EMRSA hospital outbreaks
title_short Increased EMRSA-15 health-care worker colonization demonstrated in retrospective review of EMRSA hospital outbreaks
title_sort increased emrsa-15 health-care worker colonization demonstrated in retrospective review of emrsa hospital outbreaks
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944736/
https://www.ncbi.nlm.nih.gov/pubmed/24588849
http://dx.doi.org/10.1186/2047-2994-3-7
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