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Interaction between Neuronal Nitric-Oxide Synthase and Tetrahydrobiopterin Revisited: Studies on the Nature and Mechanism of Tight Pterin Binding

[Image: see text] Recombinant neuronal nitric-oxide synthase (nNOS) expressed in baculovirus-infected Sf9 cells contains approximately 1 equiv of tightly bound tetrahydrobiopterin (BH4) per dimer and binds a second equivalent with a dissociation constant in the 10(–7)–10(–6) M range. Less is known a...

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Detalles Bibliográficos
Autores principales:	Heine, Christian L., Kolesnik, Bernd, Schmidt, Renate, Werner, Ernst R., Mayer, Bernd, Gorren, Antonius C. F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944803/ https://www.ncbi.nlm.nih.gov/pubmed/24512289 http://dx.doi.org/10.1021/bi401307r

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