Metabolic and Bactericidal Effects of Targeted Suppression of NadD and NadE Enzymes in Mycobacteria

Mycobacterium tuberculosis remains a major cause of death due to the lack of treatment accessibility, HIV coinfection, and drug resistance. Development of new drugs targeting previously unexplored pathways is essential to shorten treatment time and eliminate persistent M. tuberculosis. A promising b...

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Detalles Bibliográficos
Autores principales: Rodionova, Irina A., Schuster, Brian M., Guinn, Kristine M., Sorci, Leonardo, Scott, David A., Li, Xiaoqing, Kheterpal, Indu, Shoen, Carolyn, Cynamon, Michael, Locher, Christopher, Rubin, Eric J., Osterman, Andrei L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944813/
https://www.ncbi.nlm.nih.gov/pubmed/24549842
http://dx.doi.org/10.1128/mBio.00747-13

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