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p-Hydroxyphenylpyruvate, an Intermediate of the Phe/Tyr Catabolism, Improves Mitochondrial Oxidative Metabolism under Stressing Conditions and Prolongs Survival in Rats Subjected to Profound Hemorrhagic Shock

The aim of this study was to test the effect of a small volume administration of p-hydroxyphenylpyruvate (pHPP) in a rat model of profound hemorrhagic shock and to assess a possible metabolic mechanism of action of the compound. The results obtained show that hemorrhaged rats treated with 2–4% of th...

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Detalles Bibliográficos
Autores principales:	Cotoia, Antonella, Scrima, Rosella, Gefter, Julia V., Piccoli, Claudia, Cinnella, Gilda, Dambrosio, Michele, Fink, Mitchell P., Capitanio, Nazzareno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944966/ https://www.ncbi.nlm.nih.gov/pubmed/24599095 http://dx.doi.org/10.1371/journal.pone.0090917

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