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High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells

BACKGROUND: Synthetic lethality is an appealing technique for selectively targeting cancer cells which have acquired molecular changes that distinguish them from normal cells. High-throughput RNAi-based screens have been successfully used to identify synthetic lethal pathways with well-characterized...

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Detalles Bibliográficos
Autores principales:	Boettcher, Michael, Lawson, Andrew, Ladenburger, Viola, Fredebohm, Johannes, Wolf, Jonas, Hoheisel, Jörg D, Frezza, Christian, Shlomi, Tomer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945041/ https://www.ncbi.nlm.nih.gov/pubmed/24568598 http://dx.doi.org/10.1186/1471-2164-15-158

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