Cargando…

Intratracheal Administration of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Patient with Acute Respiratory Distress Syndrome

Umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) have been introduced as a possible therapy in acute lung injury and acute respiratory distress syndrome (ARDS). This case history is reported of a 59-yr-old man who was treated with MSCs in the course of ARDS and subsequent pulmonary f...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Youjin, Park, So Hee, Huh, Jin-Won, Lim, Chae-Man, Koh, Younsuck, Hong, Sang-Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945142/
https://www.ncbi.nlm.nih.gov/pubmed/24616596
http://dx.doi.org/10.3346/jkms.2014.29.3.438
_version_ 1782306489050857472
author Chang, Youjin
Park, So Hee
Huh, Jin-Won
Lim, Chae-Man
Koh, Younsuck
Hong, Sang-Bum
author_facet Chang, Youjin
Park, So Hee
Huh, Jin-Won
Lim, Chae-Man
Koh, Younsuck
Hong, Sang-Bum
author_sort Chang, Youjin
collection PubMed
description Umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) have been introduced as a possible therapy in acute lung injury and acute respiratory distress syndrome (ARDS). This case history is reported of a 59-yr-old man who was treated with MSCs in the course of ARDS and subsequent pulmonary fibrosis. He received a long period of mechanical ventilation and weaning proved difficult. On hospital day 114, he underwent the intratracheal administration of UCB-derived MSCs at a dose of 1 × 10(6)/kg. After cell infusion, an immediate improvement was shown in his mental status, his lung compliance (from 22.7 mL/cmH(2)O to 27.9 mL/cmH(2)O), PaO(2)/FiO(2) ratio (from 191 mmHg to 334 mmHg) and his chest radiography over the course of three days. Even though he finally died of repeated pulmonary infection, our current findings suggest the possibility of using MSCs therapy in an ARDS patient. It is the first clinical case of UCB-derived MSCs therapy ever reported.
format Online
Article
Text
id pubmed-3945142
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher The Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-39451422014-03-10 Intratracheal Administration of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Patient with Acute Respiratory Distress Syndrome Chang, Youjin Park, So Hee Huh, Jin-Won Lim, Chae-Man Koh, Younsuck Hong, Sang-Bum J Korean Med Sci Case Report Umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) have been introduced as a possible therapy in acute lung injury and acute respiratory distress syndrome (ARDS). This case history is reported of a 59-yr-old man who was treated with MSCs in the course of ARDS and subsequent pulmonary fibrosis. He received a long period of mechanical ventilation and weaning proved difficult. On hospital day 114, he underwent the intratracheal administration of UCB-derived MSCs at a dose of 1 × 10(6)/kg. After cell infusion, an immediate improvement was shown in his mental status, his lung compliance (from 22.7 mL/cmH(2)O to 27.9 mL/cmH(2)O), PaO(2)/FiO(2) ratio (from 191 mmHg to 334 mmHg) and his chest radiography over the course of three days. Even though he finally died of repeated pulmonary infection, our current findings suggest the possibility of using MSCs therapy in an ARDS patient. It is the first clinical case of UCB-derived MSCs therapy ever reported. The Korean Academy of Medical Sciences 2014-03 2014-02-27 /pmc/articles/PMC3945142/ /pubmed/24616596 http://dx.doi.org/10.3346/jkms.2014.29.3.438 Text en © 2014 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Chang, Youjin
Park, So Hee
Huh, Jin-Won
Lim, Chae-Man
Koh, Younsuck
Hong, Sang-Bum
Intratracheal Administration of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Patient with Acute Respiratory Distress Syndrome
title Intratracheal Administration of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Patient with Acute Respiratory Distress Syndrome
title_full Intratracheal Administration of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Patient with Acute Respiratory Distress Syndrome
title_fullStr Intratracheal Administration of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Patient with Acute Respiratory Distress Syndrome
title_full_unstemmed Intratracheal Administration of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Patient with Acute Respiratory Distress Syndrome
title_short Intratracheal Administration of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Patient with Acute Respiratory Distress Syndrome
title_sort intratracheal administration of umbilical cord blood-derived mesenchymal stem cells in a patient with acute respiratory distress syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945142/
https://www.ncbi.nlm.nih.gov/pubmed/24616596
http://dx.doi.org/10.3346/jkms.2014.29.3.438
work_keys_str_mv AT changyoujin intratrachealadministrationofumbilicalcordbloodderivedmesenchymalstemcellsinapatientwithacuterespiratorydistresssyndrome
AT parksohee intratrachealadministrationofumbilicalcordbloodderivedmesenchymalstemcellsinapatientwithacuterespiratorydistresssyndrome
AT huhjinwon intratrachealadministrationofumbilicalcordbloodderivedmesenchymalstemcellsinapatientwithacuterespiratorydistresssyndrome
AT limchaeman intratrachealadministrationofumbilicalcordbloodderivedmesenchymalstemcellsinapatientwithacuterespiratorydistresssyndrome
AT kohyounsuck intratrachealadministrationofumbilicalcordbloodderivedmesenchymalstemcellsinapatientwithacuterespiratorydistresssyndrome
AT hongsangbum intratrachealadministrationofumbilicalcordbloodderivedmesenchymalstemcellsinapatientwithacuterespiratorydistresssyndrome