Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect disease susceptibility. To describe the human methylome in pancreatic islets and determine the epigenetic basis of T2D, we analyzed DNA methylation of 479,927 CpG sites and the transcriptome in pancreatic islet...

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Detalles Bibliográficos
Autores principales: Dayeh, Tasnim, Volkov, Petr, Salö, Sofia, Hall, Elin, Nilsson, Emma, Olsson, Anders H., Kirkpatrick, Clare L., Wollheim, Claes B., Eliasson, Lena, Rönn, Tina, Bacos, Karl, Ling, Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945174/
https://www.ncbi.nlm.nih.gov/pubmed/24603685
http://dx.doi.org/10.1371/journal.pgen.1004160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945174/
https://www.ncbi.nlm.nih.gov/pubmed/24603685
http://dx.doi.org/10.1371/journal.pgen.1004160

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