Cargando…

Sunitinib Improves Some Clinical Aspects and Reverts DMBA-Induced Hyperplasic Lesions in Hamster Buccal Pouch

Oral squamous cell carcinoma (OSCC) is a public health problem. The hamster buccal pouch model is ideal for analyzing the development of OSCC. This research analysed the effects of sunitinib (tyrosine kinase inhibitor) in precancerous lesions induced by 7,12-dimethylbenz(a)anthracene (DMBA) in this...

Descripción completa

Detalles Bibliográficos
Autores principales: de Souza, Fernanda Lopes, Oliveira, Mariana, Nunes, Marianne Brochado, Serafim, Lucas Horstmann, Azambuja, Alan Arrieira, Braga, Luisa Maria G. de M., Saur, Lisiani, de Souza, Maria Antonieta Lopes, Xavier, Léder Leal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945207/
https://www.ncbi.nlm.nih.gov/pubmed/24693453
http://dx.doi.org/10.1155/2014/859621
_version_ 1782306496139231232
author de Souza, Fernanda Lopes
Oliveira, Mariana
Nunes, Marianne Brochado
Serafim, Lucas Horstmann
Azambuja, Alan Arrieira
Braga, Luisa Maria G. de M.
Saur, Lisiani
de Souza, Maria Antonieta Lopes
Xavier, Léder Leal
author_facet de Souza, Fernanda Lopes
Oliveira, Mariana
Nunes, Marianne Brochado
Serafim, Lucas Horstmann
Azambuja, Alan Arrieira
Braga, Luisa Maria G. de M.
Saur, Lisiani
de Souza, Maria Antonieta Lopes
Xavier, Léder Leal
author_sort de Souza, Fernanda Lopes
collection PubMed
description Oral squamous cell carcinoma (OSCC) is a public health problem. The hamster buccal pouch model is ideal for analyzing the development of OSCC. This research analysed the effects of sunitinib (tyrosine kinase inhibitor) in precancerous lesions induced by 7,12-dimethylbenz(a)anthracene (DMBA) in this model. Thirty-four male hamsters, divided into six groups: control—C (n = 7), acetone—A (n = 12), carbamide peroxide—CP (n = 5 ), acetone and CP—A+CP (n = 8), 1% DMBA in acetone and CP—DA+CP (n = 6), and 1% DMBA in acetone and CP and 4-week treatment with sunitinib—DA+CP+S (n = 7). The aspects evaluated were anatomopathological features (peribuccal area, paws, nose, and fur), histological sections of the hamster buccal pouches (qualitatively analyzed), epithelium thickness, and the rete ridge density (estimated). Sunitinib was unable to attenuate the decrease in weight gain induced by DMBA; no increase in volume was detected in the pouch and/or ulceration, observed in 43% of the animals in the DA+CP group. DA+CP groups presented a significant increase in rete ridge density compared to the control groups (P < 0.01) which was reverted by sunitinib in the DA+CP+S group. Sunitinib seems to have important benefits in early stage carcinogenesis and may be useful in chemoprevention.
format Online
Article
Text
id pubmed-3945207
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-39452072014-04-01 Sunitinib Improves Some Clinical Aspects and Reverts DMBA-Induced Hyperplasic Lesions in Hamster Buccal Pouch de Souza, Fernanda Lopes Oliveira, Mariana Nunes, Marianne Brochado Serafim, Lucas Horstmann Azambuja, Alan Arrieira Braga, Luisa Maria G. de M. Saur, Lisiani de Souza, Maria Antonieta Lopes Xavier, Léder Leal ISRN Otolaryngol Research Article Oral squamous cell carcinoma (OSCC) is a public health problem. The hamster buccal pouch model is ideal for analyzing the development of OSCC. This research analysed the effects of sunitinib (tyrosine kinase inhibitor) in precancerous lesions induced by 7,12-dimethylbenz(a)anthracene (DMBA) in this model. Thirty-four male hamsters, divided into six groups: control—C (n = 7), acetone—A (n = 12), carbamide peroxide—CP (n = 5 ), acetone and CP—A+CP (n = 8), 1% DMBA in acetone and CP—DA+CP (n = 6), and 1% DMBA in acetone and CP and 4-week treatment with sunitinib—DA+CP+S (n = 7). The aspects evaluated were anatomopathological features (peribuccal area, paws, nose, and fur), histological sections of the hamster buccal pouches (qualitatively analyzed), epithelium thickness, and the rete ridge density (estimated). Sunitinib was unable to attenuate the decrease in weight gain induced by DMBA; no increase in volume was detected in the pouch and/or ulceration, observed in 43% of the animals in the DA+CP group. DA+CP groups presented a significant increase in rete ridge density compared to the control groups (P < 0.01) which was reverted by sunitinib in the DA+CP+S group. Sunitinib seems to have important benefits in early stage carcinogenesis and may be useful in chemoprevention. Hindawi Publishing Corporation 2014-02-13 /pmc/articles/PMC3945207/ /pubmed/24693453 http://dx.doi.org/10.1155/2014/859621 Text en Copyright © 2014 Fernanda Lopes de Souza et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
de Souza, Fernanda Lopes
Oliveira, Mariana
Nunes, Marianne Brochado
Serafim, Lucas Horstmann
Azambuja, Alan Arrieira
Braga, Luisa Maria G. de M.
Saur, Lisiani
de Souza, Maria Antonieta Lopes
Xavier, Léder Leal
Sunitinib Improves Some Clinical Aspects and Reverts DMBA-Induced Hyperplasic Lesions in Hamster Buccal Pouch
title Sunitinib Improves Some Clinical Aspects and Reverts DMBA-Induced Hyperplasic Lesions in Hamster Buccal Pouch
title_full Sunitinib Improves Some Clinical Aspects and Reverts DMBA-Induced Hyperplasic Lesions in Hamster Buccal Pouch
title_fullStr Sunitinib Improves Some Clinical Aspects and Reverts DMBA-Induced Hyperplasic Lesions in Hamster Buccal Pouch
title_full_unstemmed Sunitinib Improves Some Clinical Aspects and Reverts DMBA-Induced Hyperplasic Lesions in Hamster Buccal Pouch
title_short Sunitinib Improves Some Clinical Aspects and Reverts DMBA-Induced Hyperplasic Lesions in Hamster Buccal Pouch
title_sort sunitinib improves some clinical aspects and reverts dmba-induced hyperplasic lesions in hamster buccal pouch
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945207/
https://www.ncbi.nlm.nih.gov/pubmed/24693453
http://dx.doi.org/10.1155/2014/859621
work_keys_str_mv AT desouzafernandalopes sunitinibimprovessomeclinicalaspectsandrevertsdmbainducedhyperplasiclesionsinhamsterbuccalpouch
AT oliveiramariana sunitinibimprovessomeclinicalaspectsandrevertsdmbainducedhyperplasiclesionsinhamsterbuccalpouch
AT nunesmariannebrochado sunitinibimprovessomeclinicalaspectsandrevertsdmbainducedhyperplasiclesionsinhamsterbuccalpouch
AT serafimlucashorstmann sunitinibimprovessomeclinicalaspectsandrevertsdmbainducedhyperplasiclesionsinhamsterbuccalpouch
AT azambujaalanarrieira sunitinibimprovessomeclinicalaspectsandrevertsdmbainducedhyperplasiclesionsinhamsterbuccalpouch
AT bragaluisamariagdem sunitinibimprovessomeclinicalaspectsandrevertsdmbainducedhyperplasiclesionsinhamsterbuccalpouch
AT saurlisiani sunitinibimprovessomeclinicalaspectsandrevertsdmbainducedhyperplasiclesionsinhamsterbuccalpouch
AT desouzamariaantonietalopes sunitinibimprovessomeclinicalaspectsandrevertsdmbainducedhyperplasiclesionsinhamsterbuccalpouch
AT xavierlederleal sunitinibimprovessomeclinicalaspectsandrevertsdmbainducedhyperplasiclesionsinhamsterbuccalpouch