An Epigenetic Signature in Peripheral Blood Associated with the Haplotype on 17q21.31, a Risk Factor for Neurodegenerative Tauopathy

Little is known about how changes in DNA methylation mediate risk for human diseases including dementia. Analysis of genome-wide methylation patterns in patients with two forms of tau-related dementia – progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) – revealed significant dif...

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Detalles Bibliográficos
Autores principales: Li, Yun, Chen, Jason A., Sears, Renee L., Gao, Fuying, Klein, Eric D., Karydas, Anna, Geschwind, Michael D., Rosen, Howard J., Boxer, Adam L., Guo, Weilong, Pellegrini, Matteo, Horvath, Steve, Miller, Bruce L., Geschwind, Daniel H., Coppola, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945475/
https://www.ncbi.nlm.nih.gov/pubmed/24603599
http://dx.doi.org/10.1371/journal.pgen.1004211
Descripción
Sumario:Little is known about how changes in DNA methylation mediate risk for human diseases including dementia. Analysis of genome-wide methylation patterns in patients with two forms of tau-related dementia – progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) – revealed significant differentially methylated probes (DMPs) in patients versus unaffected controls. Remarkably, DMPs in PSP were clustered within the 17q21.31 region, previously known to harbor the major genetic risk factor for PSP. We identified and replicated a dose-dependent effect of the risk-associated H1 haplotype on methylation levels within the region in blood and brain. These data reveal that the H1 haplotype increases risk for tauopathy via differential methylation at that locus, indicating a mediating role for methylation in dementia pathophysiology.

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