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Diesel Exhaust Exposure and the Risk of Lung Cancer—A Review of the Epidemiological Evidence

To critically evaluate the association between diesel exhaust (DE) exposure and the risk of lung cancer, we conducted a systematic review of published epidemiological evidences. To comprehensively identify original studies on the association between DE exposure and the risk of lung cancer, literatur...

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Autores principales: Sun, Yi, Bochmann, Frank, Nold, Annette, Mattenklott, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945540/
https://www.ncbi.nlm.nih.gov/pubmed/24473109
http://dx.doi.org/10.3390/ijerph110201312
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author Sun, Yi
Bochmann, Frank
Nold, Annette
Mattenklott, Markus
author_facet Sun, Yi
Bochmann, Frank
Nold, Annette
Mattenklott, Markus
author_sort Sun, Yi
collection PubMed
description To critically evaluate the association between diesel exhaust (DE) exposure and the risk of lung cancer, we conducted a systematic review of published epidemiological evidences. To comprehensively identify original studies on the association between DE exposure and the risk of lung cancer, literature searches were performed in literature databases for the period between 1970 and 2013, including bibliographies and cross-referencing. In total, 42 cohort studies and 32 case-control studies were identified in which the association between DE exposures and lung cancer was examined. In general, previous studies suffer from a series of methodological limitations, including design, exposure assessment methods and statistical analysis used. A lack of objective exposure information appears to be the main problem in interpreting epidemiological evidence. To facilitate the interpretation and comparison of previous studies, a job-exposure matrix (JEM) of DE exposures was created based on around 4,000 historical industrial measurements. The values from the JEM were considered during interpretation and comparison of previous studies. Overall, neither cohort nor case-control studies indicate a clear exposure-response relationship between DE exposure and lung cancer. Epidemiological studies published to date do not allow a valid quantification of the association between DE and lung cancer.
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spelling pubmed-39455402014-03-10 Diesel Exhaust Exposure and the Risk of Lung Cancer—A Review of the Epidemiological Evidence Sun, Yi Bochmann, Frank Nold, Annette Mattenklott, Markus Int J Environ Res Public Health To critically evaluate the association between diesel exhaust (DE) exposure and the risk of lung cancer, we conducted a systematic review of published epidemiological evidences. To comprehensively identify original studies on the association between DE exposure and the risk of lung cancer, literature searches were performed in literature databases for the period between 1970 and 2013, including bibliographies and cross-referencing. In total, 42 cohort studies and 32 case-control studies were identified in which the association between DE exposures and lung cancer was examined. In general, previous studies suffer from a series of methodological limitations, including design, exposure assessment methods and statistical analysis used. A lack of objective exposure information appears to be the main problem in interpreting epidemiological evidence. To facilitate the interpretation and comparison of previous studies, a job-exposure matrix (JEM) of DE exposures was created based on around 4,000 historical industrial measurements. The values from the JEM were considered during interpretation and comparison of previous studies. Overall, neither cohort nor case-control studies indicate a clear exposure-response relationship between DE exposure and lung cancer. Epidemiological studies published to date do not allow a valid quantification of the association between DE and lung cancer. MDPI 2014-01-27 2014-02 /pmc/articles/PMC3945540/ /pubmed/24473109 http://dx.doi.org/10.3390/ijerph110201312 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Sun, Yi
Bochmann, Frank
Nold, Annette
Mattenklott, Markus
Diesel Exhaust Exposure and the Risk of Lung Cancer—A Review of the Epidemiological Evidence
title Diesel Exhaust Exposure and the Risk of Lung Cancer—A Review of the Epidemiological Evidence
title_full Diesel Exhaust Exposure and the Risk of Lung Cancer—A Review of the Epidemiological Evidence
title_fullStr Diesel Exhaust Exposure and the Risk of Lung Cancer—A Review of the Epidemiological Evidence
title_full_unstemmed Diesel Exhaust Exposure and the Risk of Lung Cancer—A Review of the Epidemiological Evidence
title_short Diesel Exhaust Exposure and the Risk of Lung Cancer—A Review of the Epidemiological Evidence
title_sort diesel exhaust exposure and the risk of lung cancer—a review of the epidemiological evidence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945540/
https://www.ncbi.nlm.nih.gov/pubmed/24473109
http://dx.doi.org/10.3390/ijerph110201312
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