Safety, tolerability, and pharmacokinetics of the novel αv-integrin antibody EMD 525797 (DI17E6) in healthy subjects after ascending single intravenous doses

Purpose We evaluated the safety, tolerability, and pharmacokinetics (PK) of EMD 525797 (DI17E6), a humanized monoclonal antibody targeting αv-integrins, in healthy subjects. Methods In this first-in-human, double-blind, placebo-controlled, randomized Phase 1 study, healthy male volunteers were conse...

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Detalles Bibliográficos
Autores principales: Uhl, Wolfgang, Zühlsdorf, Michael, Koernicke, Thomas, Forssmann, Ulf, Kovar, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Phase I Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945639/
https://www.ncbi.nlm.nih.gov/pubmed/24242902
http://dx.doi.org/10.1007/s10637-013-0038-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945639/
https://www.ncbi.nlm.nih.gov/pubmed/24242902
http://dx.doi.org/10.1007/s10637-013-0038-5

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