Cargando…

Combinatorial Assembly of Small Molecules into Bivalent Antagonists of TrkC or TrkA Receptors

A library of peptidomimetics was assembled combinatorially into dimers on a triazine-based core. The pharmacophore corresponds to β-turns of the neurotrophin polypeptides neurotrophin-3 (NT-3), nerve growth factor (NGF), or brain-derived neurotrophic factor (BDNF). These are the natural ligands for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brahimi, Fouad, Ko, Eunhwa, Malakhov, Andrey, Burgess, Kevin, Saragovi, H. Uri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945644/ https://www.ncbi.nlm.nih.gov/pubmed/24603864 http://dx.doi.org/10.1371/journal.pone.0089617

Ejemplares similares

Uncoupling of Molecular Maturation from Peripheral Target Innervation in Nociceptors Expressing a Chimeric TrkA/TrkC Receptor
por: Gorokhova, Svetlana, et al.
Publicado: (2014)

TrkA Co-Receptors: The Janus Face of TrkA?
por: Trouvilliez, Sarah, et al.
Publicado: (2023)

The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS
por: Brahimi, Fouad, et al.
Publicado: (2016)

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation
por: Josephy-Hernandez, Sylvia, et al.
Publicado: (2019)

Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies
por: Xhima, Kristiana, et al.
Publicado: (2021)

Selective activation and down‐regulation of Trk receptors by neurotrophins in human neurons co‐expressing TrkB and TrkC
por: Ateaque, Sarah, et al.
Publicado: (2022)

TrkC promotes colorectal cancer growth and metastasis
por: Kim, Min Soo, et al.
Publicado: (2017)

Roles of TrkC Signaling in the Regulation of Tumorigenicity and Metastasis of Cancer
por: Jin, Wook
Publicado: (2020)

NGF – the TrkA to successful pain treatment
por: Kumar, Vinayak, et al.
Publicado: (2012)

A kinase-deficient TrkC receptor isoform activates Arf6–Rac1 signaling through the scaffold protein tamalin
por: Esteban, Pedro F., et al.
Publicado: (2006)

Targeted PDT Agent Eradicates TrkC Expressing Tumors via Photodynamic Therapy (PDT)
por: Kue, Chin Siang, et al.
Publicado: (2014)

Crystal Structure of a Two-Subunit TrkA Octameric Gating Ring Assembly
por: Deller, Marc C., et al.
Publicado: (2015)

Transcytosis of TrkA leads to diversification of dendritic signaling endosomes
por: Barford, Kelly, et al.
Publicado: (2018)

TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential
por: Zhang, Hanzhi, et al.
Publicado: (2020)

In retinitis pigmentosa TrkC.T1-dependent vectorial Erk activity upregulates glial TNF-α, causing selective neuronal death
por: Galán, Alba, et al.
Publicado: (2017)

Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth
por: Ménard, Marie, et al.
Publicado: (2018)

The Neurotrophin Receptor TrkC as a Novel Molecular Target of the Antineuroblastoma Action of Valproic Acid
por: Dedoni, Simona, et al.
Publicado: (2021)

Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer’s disease
por: Xhima, K., et al.
Publicado: (2020)

NGF-stimulated retrograde transport of trkA in the mammalian nervous system
Publicado: (1995)

NGF Causes TrkA to Specifically Attract Microtubules to Lipid Rafts
por: Pryor, Shona, et al.
Publicado: (2012)

NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells
por: Ruggeri, P, et al.
Publicado: (2016)

A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria
por: Feinberg, Konstantin, et al.
Publicado: (2017)

Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles
por: Mason, Ashley J., et al.
Publicado: (2023)

Enhanced TrkA signaling impairs basal forebrain-dependent behavior
por: Calvo-Enrique, Laura, et al.
Publicado: (2023)

Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (TrkA) in Mice Abolishes Osteoarthritis (OA) Pain via NGF/TrkA Intervention of Peripheral Sensitization
por: O-Sullivan, InSug, et al.
Publicado: (2022)

Srsf1 and Elavl1 act antagonistically on neuronal fate choice in the developing neocortex by controlling TrkC receptor isoform expression
por: Weber, A Ioana, et al.
Publicado: (2023)

Expression of mRNA for the neurotrophin receptor trkC in neuroblastomas with favourable tumour stage and good prognosis.
por: Rydén, M., et al.
Publicado: (1996)

Expression of TrkC Receptors in the Developing Brain of the Monodelphis opossum and Its Effect on the Development of Cortical Cells
por: Bartkowska, Katarzyna, et al.
Publicado: (2013)

Differential Clinical Significance of Neurotrophin-3 Expression according to MYCN Amplification and TrkC Expression in Neuroblastoma
por: Seo, Eunseop, et al.
Publicado: (2019)

TrkC-mediated inhibition of DJ-1 degradation is essential for direct regulation of pathogenesis of hepatocellular carcinoma
por: Kim, Min Soo, et al.
Publicado: (2022)

TrkC Intracellular Signalling in the Brain Fear Network During the Formation of a Contextual Fear Memory
por: Silva, Francisca, et al.
Publicado: (2023)

TTF1 suppresses neuroblastoma growth and induces neuroblastoma differentiation by targeting TrkA and the miR-204/TrkB axis
por: Yang, Tianyou, et al.
Publicado: (2022)

A quest for the stereo-electronic requirements for selective agonism for the neurotrophin receptors TrkA and TrkB in 17-spirocyclic-dehydroepiandrosterone derivatives
por: Narducci, Daniele, et al.
Publicado: (2023)

Gating of the TrkH Ion Channel by its Associated RCK Protein, Trka
por: Cao, Yu, et al.
Publicado: (2013)

Systems Pharmacology of the NGF Signaling Through p75 and TrkA Receptors
por: Toni, T, et al.
Publicado: (2014)

Activation of the NGF/TrkA signaling pathway attenuates diabetic erectile dysfunction
por: Hou, Yi, et al.
Publicado: (2017)

Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling
por: Ye, Mengchen, et al.
Publicado: (2018)

TrkA(+) Neurons Induce Pathologic Regeneration After Soft Tissue Trauma
por: Cherief, Masnsen, et al.
Publicado: (2022)

Dysregulated JAK2 expression by TrkC promotes metastasis potential, and EMT program of metastatic breast cancer
por: Kim, Min Soo, et al.
Publicado: (2016)

Expression of Neurotrophin-3 and trkC following Focal Cerebral Ischemia in Adult Rat Brain with Treadmill Exercise
por: Chung, Jin-Young, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_184epb88vcart5d3ddc2hd85tr