Cargando…
Kinetics of Chikungunya Infections during an Outbreak in Southern Thailand, 2008–2009
The Indian Ocean chikungunya epidemic re-emerged in Thailand in August 2008. Forty-five adults with laboratory-confirmed chikungunya in Songkhla province, Thailand were clinically assessed and serially bled throughout the acute and convalescent phase of the disease. Patient symptoms, antibody respon...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society of Tropical Medicine and Hygiene
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945684/ https://www.ncbi.nlm.nih.gov/pubmed/24493674 http://dx.doi.org/10.4269/ajtmh.12-0681 |
_version_ | 1782306560809107456 |
---|---|
author | Chusri, Sarunyou Siripaitoon, Pisud Silpapojakul, Kachornsak Hortiwakul, Thanaporn Charernmak, Boonsri Chinnawirotpisan, Piyawan Nisalak, Ananda Thaisomboonsuk, Butsaya Klungthong, Chonticha Gibbons, Robert V. Jarman, Richard G. |
author_facet | Chusri, Sarunyou Siripaitoon, Pisud Silpapojakul, Kachornsak Hortiwakul, Thanaporn Charernmak, Boonsri Chinnawirotpisan, Piyawan Nisalak, Ananda Thaisomboonsuk, Butsaya Klungthong, Chonticha Gibbons, Robert V. Jarman, Richard G. |
author_sort | Chusri, Sarunyou |
collection | PubMed |
description | The Indian Ocean chikungunya epidemic re-emerged in Thailand in August 2008. Forty-five adults with laboratory-confirmed chikungunya in Songkhla province, Thailand were clinically assessed and serially bled throughout the acute and convalescent phase of the disease. Patient symptoms, antibody responses, and viral kinetics were evaluated using observational assessments, polymerase chain reaction (PCR), and serological assays. All subjects experienced joint pain with 42 (93%) involving multiple joints; the interphalangeal most commonly affected in 91% of the subjects. The mean duration of joint pain was 5.8 days, 11 (25%) experiencing discomfort through the duration of the study. Rash was observed in 37 (82%) subjects a mean 3.5 days post onset of symptoms. Patents were positive by PCR for a mean of 5.9 days with sustained peak viral load through Day 5. The IgM antibodies appeared on Day 4 and peaked at Day 7 and IgG antibodies first appeared at Day 5 and rose steadily through Day 24. |
format | Online Article Text |
id | pubmed-3945684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The American Society of Tropical Medicine and Hygiene |
record_format | MEDLINE/PubMed |
spelling | pubmed-39456842014-03-12 Kinetics of Chikungunya Infections during an Outbreak in Southern Thailand, 2008–2009 Chusri, Sarunyou Siripaitoon, Pisud Silpapojakul, Kachornsak Hortiwakul, Thanaporn Charernmak, Boonsri Chinnawirotpisan, Piyawan Nisalak, Ananda Thaisomboonsuk, Butsaya Klungthong, Chonticha Gibbons, Robert V. Jarman, Richard G. Am J Trop Med Hyg Articles The Indian Ocean chikungunya epidemic re-emerged in Thailand in August 2008. Forty-five adults with laboratory-confirmed chikungunya in Songkhla province, Thailand were clinically assessed and serially bled throughout the acute and convalescent phase of the disease. Patient symptoms, antibody responses, and viral kinetics were evaluated using observational assessments, polymerase chain reaction (PCR), and serological assays. All subjects experienced joint pain with 42 (93%) involving multiple joints; the interphalangeal most commonly affected in 91% of the subjects. The mean duration of joint pain was 5.8 days, 11 (25%) experiencing discomfort through the duration of the study. Rash was observed in 37 (82%) subjects a mean 3.5 days post onset of symptoms. Patents were positive by PCR for a mean of 5.9 days with sustained peak viral load through Day 5. The IgM antibodies appeared on Day 4 and peaked at Day 7 and IgG antibodies first appeared at Day 5 and rose steadily through Day 24. The American Society of Tropical Medicine and Hygiene 2014-03-05 /pmc/articles/PMC3945684/ /pubmed/24493674 http://dx.doi.org/10.4269/ajtmh.12-0681 Text en ©The American Society of Tropical Medicine and Hygiene This is an Open Access article distributed under the terms of the American Society of Tropical Medicine and Hygiene's Re-use License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Chusri, Sarunyou Siripaitoon, Pisud Silpapojakul, Kachornsak Hortiwakul, Thanaporn Charernmak, Boonsri Chinnawirotpisan, Piyawan Nisalak, Ananda Thaisomboonsuk, Butsaya Klungthong, Chonticha Gibbons, Robert V. Jarman, Richard G. Kinetics of Chikungunya Infections during an Outbreak in Southern Thailand, 2008–2009 |
title | Kinetics of Chikungunya Infections during an Outbreak in Southern Thailand, 2008–2009 |
title_full | Kinetics of Chikungunya Infections during an Outbreak in Southern Thailand, 2008–2009 |
title_fullStr | Kinetics of Chikungunya Infections during an Outbreak in Southern Thailand, 2008–2009 |
title_full_unstemmed | Kinetics of Chikungunya Infections during an Outbreak in Southern Thailand, 2008–2009 |
title_short | Kinetics of Chikungunya Infections during an Outbreak in Southern Thailand, 2008–2009 |
title_sort | kinetics of chikungunya infections during an outbreak in southern thailand, 2008–2009 |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945684/ https://www.ncbi.nlm.nih.gov/pubmed/24493674 http://dx.doi.org/10.4269/ajtmh.12-0681 |
work_keys_str_mv | AT chusrisarunyou kineticsofchikungunyainfectionsduringanoutbreakinsouthernthailand20082009 AT siripaitoonpisud kineticsofchikungunyainfectionsduringanoutbreakinsouthernthailand20082009 AT silpapojakulkachornsak kineticsofchikungunyainfectionsduringanoutbreakinsouthernthailand20082009 AT hortiwakulthanaporn kineticsofchikungunyainfectionsduringanoutbreakinsouthernthailand20082009 AT charernmakboonsri kineticsofchikungunyainfectionsduringanoutbreakinsouthernthailand20082009 AT chinnawirotpisanpiyawan kineticsofchikungunyainfectionsduringanoutbreakinsouthernthailand20082009 AT nisalakananda kineticsofchikungunyainfectionsduringanoutbreakinsouthernthailand20082009 AT thaisomboonsukbutsaya kineticsofchikungunyainfectionsduringanoutbreakinsouthernthailand20082009 AT klungthongchonticha kineticsofchikungunyainfectionsduringanoutbreakinsouthernthailand20082009 AT gibbonsrobertv kineticsofchikungunyainfectionsduringanoutbreakinsouthernthailand20082009 AT jarmanrichardg kineticsofchikungunyainfectionsduringanoutbreakinsouthernthailand20082009 |