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Does Maturity Affect Cephalic Perfusion and T/QRS Ratio during Prolonged Umbilical Cord Occlusion in Fetal Sheep?

T/QRS ratio monitoring is used to help identify fetal asphyxia. However, immature animals have greater capacity to maintain blood pressure during severe asphyxia, raising the possibility that they may show an attenuated T/QRS increase during asphyxia. Chronically instrumented fetal sheep at 0.6 of g...

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Autores principales: Wassink, Guido, Galinsky, Robert, Drury, Paul P., Gunn, Eleanor R., Bennet, Laura, Gunn, Alistair J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945773/
https://www.ncbi.nlm.nih.gov/pubmed/24693290
http://dx.doi.org/10.1155/2014/314159
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author Wassink, Guido
Galinsky, Robert
Drury, Paul P.
Gunn, Eleanor R.
Bennet, Laura
Gunn, Alistair J.
author_facet Wassink, Guido
Galinsky, Robert
Drury, Paul P.
Gunn, Eleanor R.
Bennet, Laura
Gunn, Alistair J.
author_sort Wassink, Guido
collection PubMed
description T/QRS ratio monitoring is used to help identify fetal asphyxia. However, immature animals have greater capacity to maintain blood pressure during severe asphyxia, raising the possibility that they may show an attenuated T/QRS increase during asphyxia. Chronically instrumented fetal sheep at 0.6 of gestation (0.6 GA; n = 12), 0.7 GA (n = 12), and 0.8 GA (n = 8) underwent complete umbilical cord occlusion for 30 min, 25 min, or 15 min, respectively. Cord occlusion was associated with progressive metabolic acidosis and initial hypertension followed by severe hypotension, with a more rapid fall in mean arterial blood pressure (MAP) and carotid blood flow (CaBF) with advancing gestation. T/QRS ratio rose after occlusion more rapidly at 0.8 GA than in immature fetuses, to a similar final peak at all ages, followed by a progressive fall that was slower at 0.8 GA than in the immature fetuses. The increase in T/QRS ratio correlated with initial hypertension at 0.8 GA (P < 0.05, R (2) = 0.38), and conversely, its fall correlated closely with falling MAP in all gestational groups (P < 0.01, R (2) = 0.67). In conclusion, elevation of the T/QRS ratio is an index of onset of severe asphyxia in the last third of gestation, but not of fetal compromise.
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spelling pubmed-39457732014-04-01 Does Maturity Affect Cephalic Perfusion and T/QRS Ratio during Prolonged Umbilical Cord Occlusion in Fetal Sheep? Wassink, Guido Galinsky, Robert Drury, Paul P. Gunn, Eleanor R. Bennet, Laura Gunn, Alistair J. Obstet Gynecol Int Research Article T/QRS ratio monitoring is used to help identify fetal asphyxia. However, immature animals have greater capacity to maintain blood pressure during severe asphyxia, raising the possibility that they may show an attenuated T/QRS increase during asphyxia. Chronically instrumented fetal sheep at 0.6 of gestation (0.6 GA; n = 12), 0.7 GA (n = 12), and 0.8 GA (n = 8) underwent complete umbilical cord occlusion for 30 min, 25 min, or 15 min, respectively. Cord occlusion was associated with progressive metabolic acidosis and initial hypertension followed by severe hypotension, with a more rapid fall in mean arterial blood pressure (MAP) and carotid blood flow (CaBF) with advancing gestation. T/QRS ratio rose after occlusion more rapidly at 0.8 GA than in immature fetuses, to a similar final peak at all ages, followed by a progressive fall that was slower at 0.8 GA than in the immature fetuses. The increase in T/QRS ratio correlated with initial hypertension at 0.8 GA (P < 0.05, R (2) = 0.38), and conversely, its fall correlated closely with falling MAP in all gestational groups (P < 0.01, R (2) = 0.67). In conclusion, elevation of the T/QRS ratio is an index of onset of severe asphyxia in the last third of gestation, but not of fetal compromise. Hindawi Publishing Corporation 2014 2014-02-16 /pmc/articles/PMC3945773/ /pubmed/24693290 http://dx.doi.org/10.1155/2014/314159 Text en Copyright © 2014 Guido Wassink et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wassink, Guido
Galinsky, Robert
Drury, Paul P.
Gunn, Eleanor R.
Bennet, Laura
Gunn, Alistair J.
Does Maturity Affect Cephalic Perfusion and T/QRS Ratio during Prolonged Umbilical Cord Occlusion in Fetal Sheep?
title Does Maturity Affect Cephalic Perfusion and T/QRS Ratio during Prolonged Umbilical Cord Occlusion in Fetal Sheep?
title_full Does Maturity Affect Cephalic Perfusion and T/QRS Ratio during Prolonged Umbilical Cord Occlusion in Fetal Sheep?
title_fullStr Does Maturity Affect Cephalic Perfusion and T/QRS Ratio during Prolonged Umbilical Cord Occlusion in Fetal Sheep?
title_full_unstemmed Does Maturity Affect Cephalic Perfusion and T/QRS Ratio during Prolonged Umbilical Cord Occlusion in Fetal Sheep?
title_short Does Maturity Affect Cephalic Perfusion and T/QRS Ratio during Prolonged Umbilical Cord Occlusion in Fetal Sheep?
title_sort does maturity affect cephalic perfusion and t/qrs ratio during prolonged umbilical cord occlusion in fetal sheep?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945773/
https://www.ncbi.nlm.nih.gov/pubmed/24693290
http://dx.doi.org/10.1155/2014/314159
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