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Determination of carbohydrate-deficient transferrin in a Han Chinese population
BACKGROUND: Carbohydrate-deficient transferrin (CDT) is a widely used alcohol biomarker. Because of the high prevalence of chronic alcohol abuse in many countries, CDT plays an important role in the areas of traffic, clinical, and forensic medicine. However, CDT levels have not been determined in th...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945810/ https://www.ncbi.nlm.nih.gov/pubmed/24571498 http://dx.doi.org/10.1186/1471-2091-15-5 |
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author | Song, Binbin Zhu, Jing Wu, Jiong Zhang, Chunyan Wang, Beili Pan, Baishen Guo, Wei |
author_facet | Song, Binbin Zhu, Jing Wu, Jiong Zhang, Chunyan Wang, Beili Pan, Baishen Guo, Wei |
author_sort | Song, Binbin |
collection | PubMed |
description | BACKGROUND: Carbohydrate-deficient transferrin (CDT) is a widely used alcohol biomarker. Because of the high prevalence of chronic alcohol abuse in many countries, CDT plays an important role in the areas of traffic, clinical, and forensic medicine. However, CDT levels have not been determined in the Han Chinese population. Therefore, we investigated the frequency of genetic transferrin variants and the relationship between CDT levels and alcohol consumption in this population. From this data, we established a CDT cut-off for Han Chinese and evaluated the analytical performance of the CDT capillary zone electrophoresis system. RESULTS: The prevalence of transferrin variants was 4.14%. The mean CDT level of the reference group was 0.73%. We recommended CDT level >1.5% as cut off standard of alcohol intake to ensuring the specificity was best. The CDT test total precision for 0.5%, 0.7%, and 1.55% was 14.4%, 11.5%, and 7.2%, respectively. The data showed good linearity in the studied range of 0.6% to 8.2%. CONCLUSIONS: These results demonstrate that CDT is a useful marker to detect heavy daily alcohol consumption. We proposed and evaluated the first CDT cut-off for the Han Chinese population, and we showed that the CDT capillary zone electrophoresis system is a reliable analytic method. |
format | Online Article Text |
id | pubmed-3945810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39458102014-03-08 Determination of carbohydrate-deficient transferrin in a Han Chinese population Song, Binbin Zhu, Jing Wu, Jiong Zhang, Chunyan Wang, Beili Pan, Baishen Guo, Wei BMC Biochem Methodology Article BACKGROUND: Carbohydrate-deficient transferrin (CDT) is a widely used alcohol biomarker. Because of the high prevalence of chronic alcohol abuse in many countries, CDT plays an important role in the areas of traffic, clinical, and forensic medicine. However, CDT levels have not been determined in the Han Chinese population. Therefore, we investigated the frequency of genetic transferrin variants and the relationship between CDT levels and alcohol consumption in this population. From this data, we established a CDT cut-off for Han Chinese and evaluated the analytical performance of the CDT capillary zone electrophoresis system. RESULTS: The prevalence of transferrin variants was 4.14%. The mean CDT level of the reference group was 0.73%. We recommended CDT level >1.5% as cut off standard of alcohol intake to ensuring the specificity was best. The CDT test total precision for 0.5%, 0.7%, and 1.55% was 14.4%, 11.5%, and 7.2%, respectively. The data showed good linearity in the studied range of 0.6% to 8.2%. CONCLUSIONS: These results demonstrate that CDT is a useful marker to detect heavy daily alcohol consumption. We proposed and evaluated the first CDT cut-off for the Han Chinese population, and we showed that the CDT capillary zone electrophoresis system is a reliable analytic method. BioMed Central 2014-02-27 /pmc/articles/PMC3945810/ /pubmed/24571498 http://dx.doi.org/10.1186/1471-2091-15-5 Text en Copyright © 2014 Song et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Methodology Article Song, Binbin Zhu, Jing Wu, Jiong Zhang, Chunyan Wang, Beili Pan, Baishen Guo, Wei Determination of carbohydrate-deficient transferrin in a Han Chinese population |
title | Determination of carbohydrate-deficient transferrin in a Han Chinese population |
title_full | Determination of carbohydrate-deficient transferrin in a Han Chinese population |
title_fullStr | Determination of carbohydrate-deficient transferrin in a Han Chinese population |
title_full_unstemmed | Determination of carbohydrate-deficient transferrin in a Han Chinese population |
title_short | Determination of carbohydrate-deficient transferrin in a Han Chinese population |
title_sort | determination of carbohydrate-deficient transferrin in a han chinese population |
topic | Methodology Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945810/ https://www.ncbi.nlm.nih.gov/pubmed/24571498 http://dx.doi.org/10.1186/1471-2091-15-5 |
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