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Determination of carbohydrate-deficient transferrin in a Han Chinese population

BACKGROUND: Carbohydrate-deficient transferrin (CDT) is a widely used alcohol biomarker. Because of the high prevalence of chronic alcohol abuse in many countries, CDT plays an important role in the areas of traffic, clinical, and forensic medicine. However, CDT levels have not been determined in th...

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Autores principales: Song, Binbin, Zhu, Jing, Wu, Jiong, Zhang, Chunyan, Wang, Beili, Pan, Baishen, Guo, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945810/
https://www.ncbi.nlm.nih.gov/pubmed/24571498
http://dx.doi.org/10.1186/1471-2091-15-5
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author Song, Binbin
Zhu, Jing
Wu, Jiong
Zhang, Chunyan
Wang, Beili
Pan, Baishen
Guo, Wei
author_facet Song, Binbin
Zhu, Jing
Wu, Jiong
Zhang, Chunyan
Wang, Beili
Pan, Baishen
Guo, Wei
author_sort Song, Binbin
collection PubMed
description BACKGROUND: Carbohydrate-deficient transferrin (CDT) is a widely used alcohol biomarker. Because of the high prevalence of chronic alcohol abuse in many countries, CDT plays an important role in the areas of traffic, clinical, and forensic medicine. However, CDT levels have not been determined in the Han Chinese population. Therefore, we investigated the frequency of genetic transferrin variants and the relationship between CDT levels and alcohol consumption in this population. From this data, we established a CDT cut-off for Han Chinese and evaluated the analytical performance of the CDT capillary zone electrophoresis system. RESULTS: The prevalence of transferrin variants was 4.14%. The mean CDT level of the reference group was 0.73%. We recommended CDT level >1.5% as cut off standard of alcohol intake to ensuring the specificity was best. The CDT test total precision for 0.5%, 0.7%, and 1.55% was 14.4%, 11.5%, and 7.2%, respectively. The data showed good linearity in the studied range of 0.6% to 8.2%. CONCLUSIONS: These results demonstrate that CDT is a useful marker to detect heavy daily alcohol consumption. We proposed and evaluated the first CDT cut-off for the Han Chinese population, and we showed that the CDT capillary zone electrophoresis system is a reliable analytic method.
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spelling pubmed-39458102014-03-08 Determination of carbohydrate-deficient transferrin in a Han Chinese population Song, Binbin Zhu, Jing Wu, Jiong Zhang, Chunyan Wang, Beili Pan, Baishen Guo, Wei BMC Biochem Methodology Article BACKGROUND: Carbohydrate-deficient transferrin (CDT) is a widely used alcohol biomarker. Because of the high prevalence of chronic alcohol abuse in many countries, CDT plays an important role in the areas of traffic, clinical, and forensic medicine. However, CDT levels have not been determined in the Han Chinese population. Therefore, we investigated the frequency of genetic transferrin variants and the relationship between CDT levels and alcohol consumption in this population. From this data, we established a CDT cut-off for Han Chinese and evaluated the analytical performance of the CDT capillary zone electrophoresis system. RESULTS: The prevalence of transferrin variants was 4.14%. The mean CDT level of the reference group was 0.73%. We recommended CDT level >1.5% as cut off standard of alcohol intake to ensuring the specificity was best. The CDT test total precision for 0.5%, 0.7%, and 1.55% was 14.4%, 11.5%, and 7.2%, respectively. The data showed good linearity in the studied range of 0.6% to 8.2%. CONCLUSIONS: These results demonstrate that CDT is a useful marker to detect heavy daily alcohol consumption. We proposed and evaluated the first CDT cut-off for the Han Chinese population, and we showed that the CDT capillary zone electrophoresis system is a reliable analytic method. BioMed Central 2014-02-27 /pmc/articles/PMC3945810/ /pubmed/24571498 http://dx.doi.org/10.1186/1471-2091-15-5 Text en Copyright © 2014 Song et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Methodology Article
Song, Binbin
Zhu, Jing
Wu, Jiong
Zhang, Chunyan
Wang, Beili
Pan, Baishen
Guo, Wei
Determination of carbohydrate-deficient transferrin in a Han Chinese population
title Determination of carbohydrate-deficient transferrin in a Han Chinese population
title_full Determination of carbohydrate-deficient transferrin in a Han Chinese population
title_fullStr Determination of carbohydrate-deficient transferrin in a Han Chinese population
title_full_unstemmed Determination of carbohydrate-deficient transferrin in a Han Chinese population
title_short Determination of carbohydrate-deficient transferrin in a Han Chinese population
title_sort determination of carbohydrate-deficient transferrin in a han chinese population
topic Methodology Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945810/
https://www.ncbi.nlm.nih.gov/pubmed/24571498
http://dx.doi.org/10.1186/1471-2091-15-5
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