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What do grid cells contribute to place cell firing?

The unitary firing fields of hippocampal place cells are commonly assumed to be generated by input from entorhinal grid cell modules with differing spatial scales. Here, we review recent research that brings this assumption into doubt. Instead, we propose that place cell spatial firing patterns are...

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Detalles Bibliográficos
Autores principales: Bush, Daniel, Barry, Caswell, Burgess, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Applied Science Publishing 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945817/
https://www.ncbi.nlm.nih.gov/pubmed/24485517
http://dx.doi.org/10.1016/j.tins.2013.12.003
Descripción
Sumario:The unitary firing fields of hippocampal place cells are commonly assumed to be generated by input from entorhinal grid cell modules with differing spatial scales. Here, we review recent research that brings this assumption into doubt. Instead, we propose that place cell spatial firing patterns are determined by environmental sensory inputs, including those representing the distance and direction to environmental boundaries, while grid cells provide a complementary self-motion related input that contributes to maintaining place cell firing. In this view, grid and place cell firing patterns are not successive stages of a processing hierarchy, but complementary and interacting representations that work in combination to support the reliable coding of large-scale space.