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Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems

Protein alkylation by reactive electrophiles contributes to chemical toxicities and oxidative stress, but the functional impact of alkylation damage across proteomes is poorly understood. We used Click chemistry and shotgun proteomics to profile the accumulation of proteome damage in human cells tre...

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Detalles Bibliográficos
Autores principales:	Codreanu, Simona G., Ullery, Jody C., Zhu, Jing, Tallman, Keri A., Beavers, William N., Porter, Ned A., Marnett, Lawrence J., Zhang, Bing, Liebler, Daniel C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945913/ https://www.ncbi.nlm.nih.gov/pubmed/24429493 http://dx.doi.org/10.1074/mcp.M113.032953

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