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Surveillance of antimalarial drug resistance in China in the 1980s–1990s
Since the successful preparation of the microplates and the medium for field application, the resistance degree and its geographical distribution of chloroquine-resistant Plasmodium falciparum, the fluctuation of the resistance degree of P. falciparum to chloroquine, and the sensitivity of the paras...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946046/ https://www.ncbi.nlm.nih.gov/pubmed/24565422 http://dx.doi.org/10.1186/2049-9957-3-8 |
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author | Liu, De-quan |
author_facet | Liu, De-quan |
author_sort | Liu, De-quan |
collection | PubMed |
description | Since the successful preparation of the microplates and the medium for field application, the resistance degree and its geographical distribution of chloroquine-resistant Plasmodium falciparum, the fluctuation of the resistance degree of P. falciparum to chloroquine, and the sensitivity of the parasite to commonly used antimalarial drugs were investigated between 1980 and 2003 by the in vitro microtest and the in vivo four-week test recommended by the World Health Organization (WHO). The results indicated that chloroquine-resistant falciparum malaria was present in all eight provinces/autonomous regions endemic for falciparum malaria in China, and the resistance was high and widely distributed in the Hainan and Yunnan provinces. When the use of chloroquine was stopped or administered in a decreased quanity, the drug resistance gradually decreased. In Hainan and Yunnan, P. falciparum was still highly resistant to chloroquine, amodiaquine and piperaquine, and sensitive to pyronaridine and artemisinin derivatives, but the sensitivity was gradually reduced. Based on these results, principles and therapeutic regimens for antimalarial drug use in China were formulated, the use of the antimalarials which had already developed resistance was stopped or reduced, and recommendations to use artemisinin derivatives or compound pyronaridine to promote a rational use of antimalarials and strengthen malaria control were made. The results showed that malaria incidence had declined, and endemic areas of falciparum malaria have been gradually reducing since the mid-1980s. |
format | Online Article Text |
id | pubmed-3946046 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39460462014-03-09 Surveillance of antimalarial drug resistance in China in the 1980s–1990s Liu, De-quan Infect Dis Poverty Scoping Review Since the successful preparation of the microplates and the medium for field application, the resistance degree and its geographical distribution of chloroquine-resistant Plasmodium falciparum, the fluctuation of the resistance degree of P. falciparum to chloroquine, and the sensitivity of the parasite to commonly used antimalarial drugs were investigated between 1980 and 2003 by the in vitro microtest and the in vivo four-week test recommended by the World Health Organization (WHO). The results indicated that chloroquine-resistant falciparum malaria was present in all eight provinces/autonomous regions endemic for falciparum malaria in China, and the resistance was high and widely distributed in the Hainan and Yunnan provinces. When the use of chloroquine was stopped or administered in a decreased quanity, the drug resistance gradually decreased. In Hainan and Yunnan, P. falciparum was still highly resistant to chloroquine, amodiaquine and piperaquine, and sensitive to pyronaridine and artemisinin derivatives, but the sensitivity was gradually reduced. Based on these results, principles and therapeutic regimens for antimalarial drug use in China were formulated, the use of the antimalarials which had already developed resistance was stopped or reduced, and recommendations to use artemisinin derivatives or compound pyronaridine to promote a rational use of antimalarials and strengthen malaria control were made. The results showed that malaria incidence had declined, and endemic areas of falciparum malaria have been gradually reducing since the mid-1980s. BioMed Central 2014-02-24 /pmc/articles/PMC3946046/ /pubmed/24565422 http://dx.doi.org/10.1186/2049-9957-3-8 Text en Copyright © 2014 LIU; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Scoping Review Liu, De-quan Surveillance of antimalarial drug resistance in China in the 1980s–1990s |
title | Surveillance of antimalarial drug resistance in China in the 1980s–1990s |
title_full | Surveillance of antimalarial drug resistance in China in the 1980s–1990s |
title_fullStr | Surveillance of antimalarial drug resistance in China in the 1980s–1990s |
title_full_unstemmed | Surveillance of antimalarial drug resistance in China in the 1980s–1990s |
title_short | Surveillance of antimalarial drug resistance in China in the 1980s–1990s |
title_sort | surveillance of antimalarial drug resistance in china in the 1980s–1990s |
topic | Scoping Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946046/ https://www.ncbi.nlm.nih.gov/pubmed/24565422 http://dx.doi.org/10.1186/2049-9957-3-8 |
work_keys_str_mv | AT liudequan surveillanceofantimalarialdrugresistanceinchinainthe1980s1990s |