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Triple Immunoglobulin Gene Knockout Transchromosomic Cattle: Bovine Lambda Cluster Deletion and Its Effect on Fully Human Polyclonal Antibody Production

Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin (Ig) heavy-chain (hIGH), kappa-chain (hIGK), an...

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Detalles Bibliográficos
Autores principales:	Matsushita, Hiroaki, Sano, Akiko, Wu, Hua, Jiao, Jin-an, Kasinathan, Poothappillai, Sullivan, Eddie J., Wang, Zhongde, Kuroiwa, Yoshimi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946162/ https://www.ncbi.nlm.nih.gov/pubmed/24603704 http://dx.doi.org/10.1371/journal.pone.0090383

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