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Rapid induction of Alternative Lengthening of Telomeres by depletion of the histone chaperone ASF1

The mechanism of activation of the Alternative Lengthening of Telomeres (ALT) pathway of mammalian chromosome end maintenance has remained an unresolved issue. We have discovered that co-depletion of the histone chaperones ASF1a and ASF1b in human cells induced all hallmarks of ALT in both primary a...

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Detalles Bibliográficos
Autores principales:	O’Sullivan, Roderick J., Arnoult, Nausica, Lackner, Daniel H., Oganesian, Liana, Haggblom, Candy, Corpet, Armelle, Almouzni, Genevieve, Karlseder, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946341/ https://www.ncbi.nlm.nih.gov/pubmed/24413054 http://dx.doi.org/10.1038/nsmb.2754

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