Cargando…
PPARγ Agonists Improve Survival and Neurocognitive Outcomes in Experimental Cerebral Malaria and Induce Neuroprotective Pathways in Human Malaria
Cerebral malaria (CM) is associated with a high mortality rate, and long-term neurocognitive impairment in approximately one third of survivors. Adjunctive therapies that modify the pathophysiological processes involved in CM may improve outcome over anti-malarial therapy alone. PPARγ agonists have...
Autores principales: | Serghides, Lena, McDonald, Chloe R., Lu, Ziyue, Friedel, Miriam, Cui, Cheryl, Ho, Keith T., Mount, Howard T. J., Sled, John G., Kain, Kevin C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946361/ https://www.ncbi.nlm.nih.gov/pubmed/24603727 http://dx.doi.org/10.1371/journal.ppat.1003980 |
Ejemplares similares
-
The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria
por: Serghides, Lena
Publicado: (2012) -
Experimental Malaria in Pregnancy Induces Neurocognitive Injury in Uninfected Offspring via a C5a-C5a Receptor Dependent Pathway
por: McDonald, Chloë R., et al.
Publicado: (2015) -
Inhaled Nitric Oxide Reduces Endothelial Activation and Parasite Accumulation in the Brain, and Enhances Survival in Experimental Cerebral Malaria
por: Serghides, Lena, et al.
Publicado: (2011) -
The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys
por: Swanson, Christine R, et al.
Publicado: (2011) -
Adjunctive therapy for severe malaria: a review and critical appraisal
por: Varo, Rosauro, et al.
Publicado: (2018)