Cargando…

Chronic Exposure to Type-I IFN under Lymphopenic Conditions Alters CD4 T Cell Homeostasis

HIV infection and the associated chronic immune activation alter T cell homeostasis leading to CD4 T cell depletion and CD8 T cell expansion. The mechanisms behind these outcomes are not totally defined and only partially explained by the direct cytopathic effect of the virus. In this manuscript, we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Le Saout, Cecile, Hasley, Rebecca B., Imamichi, Hiromi, Tcheung, Lueng, Hu, Zonghui, Luckey, Megan A., Park, Jung-Hyun, Durum, Scott K., Smith, Mindy, Rupert, Adam W., Sneller, Michael C., Lane, H. Clifford, Catalfamo, Marta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946368/ https://www.ncbi.nlm.nih.gov/pubmed/24603698 http://dx.doi.org/10.1371/journal.ppat.1003976

Ejemplares similares

IL-2 Mediates CD4(+) T Cell Help in the Breakdown of Memory-Like CD8(+) T Cell Tolerance under Lymphopenic Conditions
por: Le Saout, Cécile, et al.
Publicado: (2010)

Activated platelet–T-cell conjugates in peripheral blood of patients with HIV infection: coupling coagulation/inflammation and T cells
por: Green, Samantha A., et al.
Publicado: (2015)

CD24 Expression on T Cells Is Required for Optimal T Cell Proliferation in Lymphopenic Host
por: Li, Ou, et al.
Publicado: (2004)

Defective HIV-1 proviruses produce viral proteins
por: Imamichi, Hiromi, et al.
Publicado: (2020)

The role of protease-activated receptor 1 signaling in CD8 T cell effector functions
por: Chen, Hui, et al.
Publicado: (2021)

Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts
por: Li, Ou, et al.
Publicado: (2006)

RESPONSE OF LYMPHOPENIC PLATELETPHERESIS DONORS TO COVID-19 VACCINATION
por: Bazin, Renee, et al.
Publicado: (2023)

Inflammasome activation and pyroptosis in lymphopenic liver patients with COVID-19
por: Kroemer, Alexander, et al.
Publicado: (2020)

Lymphopenic community acquired pneumonia as signature of severe COVID-19 infection
por: Bermejo-Martin, Jesús F, et al.
Publicado: (2020)

Interferon-γ Receptor Signaling in Dendritic Cells Restrains Spontaneous Proliferation of CD4(+) T Cells in Chronic Lymphopenic Mice
por: Knop, Laura, et al.
Publicado: (2019)

Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts
por: Quezada, Sergio A., et al.
Publicado: (2010)

Non-lymphopenic pneumocystis pneumonia in low-dose methotrexate therapy: An exception to every rule
por: Lourenço, Jorge, et al.
Publicado: (2020)

Immune Adjuvant Therapy With Interleukin-7 in a Lymphopenic Patient With Aplastic Anemia and Mucormycosis
por: Crees, Zachary D., et al.
Publicado: (2023)

Programed death-1/programed death-ligand 1 expression in lymph nodes of HIV infected patients: results of a pilot safety study in rhesus macaques using anti–programed death-ligand 1 (Avelumab)
por: Gill, Amanda L., et al.
Publicado: (2016)

Lymphopenic Community Acquired Pneumonia (L-CAP), an Immunological Phenotype Associated with Higher Risk of Mortality
por: Bermejo-Martin, Jesus F., et al.
Publicado: (2017)

Allergen Exposure in Lymphopenic Fas-Deficient Mice Results in Persistent Eosinophilia Due to Defects in Resolution of Inflammation
por: Ferreira, Caroline M., et al.
Publicado: (2018)

Long-term persistence of transcriptionally active ‘defective’ HIV-1 proviruses: implications for persistent immune activation during antiretroviral therapy
por: Singh, Kanal, et al.
Publicado: (2023)

Pembrolizumab in Lymphopenic Metastatic Breast Cancer Patients Treated with Metronomic Cyclophosphamide: A Clinical and Translational Prospective Study
por: Mery, Benoîte, et al.
Publicado: (2023)

2516. Persistence of Anti-HIV Antibodies in HIV-1-infected Patients on Combination Antiretroviral Therapy (cART) with Prolonged Viral Suppression
por: Singh, Kanal, et al.
Publicado: (2019)

IL7-Fc Enhances the Efficacy of Adoptive T Cell Therapy under Lymphopenic Conditions in a Murine Melanoma Model
por: Yu, Eun M., et al.
Publicado: (2021)

Antibiotic administration exacerbates acute graft vs. host disease-induced bone marrow and spleen damage in lymphopenic mice
por: McDaniel Mims, Brianyell, et al.
Publicado: (2021)

A flow-cytometry-based assay to assess granule exocytosis and GZB delivery by human CD8 T cells and NK cells
por: Li, Tong, et al.
Publicado: (2022)

Plasma Interleukin-27 (IL-27) Levels Are Not Modulated in Patients with Chronic HIV-1 Infection
por: Swaminathan, Sanjay, et al.
Publicado: (2014)

HIV-1 Treated Patients with Undetectable Viral Loads have Lower Levels of Innate Immune Responses via Cytosolic DNA Sensing Systems Compared with Healthy Uninfected Controls
por: Swaminathan, Sanjay, et al.
Publicado: (2014)

Interleukin-15 (IL-15) Strongly Correlates with Increasing HIV-1 Viremia and Markers of Inflammation
por: Swaminathan, Sanjay, et al.
Publicado: (2016)

Epigenetic regulation of gene expression and cellular differentiation
por: Barski, Artem, et al.
Publicado: (2014)

Adjuvant therapeutic vaccination in patients with non-small cell lung cancer made lymphopenic and reconstituted with autologous PBMC: first clinical experience and evidence of an immune response
por: Rüttinger, Dominik, et al.
Publicado: (2007)

Rapid Recall Ability of Memory T cells is Encoded in their Epigenome
por: Barski, Artem, et al.
Publicado: (2017)

siRNA enhances DNA-mediated interferon lambda-1 response through crosstalk between RIG-I and IFI16 signalling pathway
por: Sui, Hongyan, et al.
Publicado: (2014)

Regulation of IFN-Is by MEF2D Promotes Inflammatory Homeostasis in Microglia
por: Lu, Fangfang, et al.
Publicado: (2021)

Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47(phox)
por: Sowrirajan, Bharatwaj, et al.
Publicado: (2017)

HIV-1 infected monozygotic twins: a tale of two outcomes
por: Tazi, Loubna, et al.
Publicado: (2011)

IL-27 induces IFN/STAT1-dependent genes and enhances function of TIGIT(+) HIVGag-specific T cells
por: Cheng, Jie, et al.
Publicado: (2021)

Genome-wide association study of high-sensitivity C-reactive protein, D-dimer, and interleukin-6 levels in multiethnic HIV+ cohorts
por: Sherman, Brad T., et al.
Publicado: (2021)

IFN-γ and CD38 in Hyperprogressive Cancer Development
por: Angelicola, Stefania, et al.
Publicado: (2021)

CD4(+) T Helper Cells Play a Key Role in Maintaining Diabetogenic CD8(+) T Cell Function in the Pancreas
por: Espinosa-Carrasco, Gabriel, et al.
Publicado: (2018)

Schistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways
por: Yegorov, Sergey, et al.
Publicado: (2019)

FoxP3(+)CD4(+), IFN-γ(+)CD4(+), and IFN-γ(+)CD8(+) cell levels in erosive and non-erosive types of oral lichen planus patients
por: Sun, Andy, et al.
Publicado: (2021)

CD160 is essential for NK-mediated IFN-γ production
por: Tu, Tony C., et al.
Publicado: (2015)

Fine-tuning of type I IFN-signaling in microglia — implications for homeostasis, CNS autoimmunity and interferonopathies
por: Goldmann, Tobias, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_5ji65aj2vpbvhifuluckd65bn1