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Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China
To identify optimal cut-off points of fasting plasma glucose for two-step strategy in screening of undiagnosed diabetes in Chinese people, data were selected from two cross-sectional studies of Metabolic Syndrome in Zhejiang Province of China, Zhejiang Statistical Yearbook (2010), and published lite...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946449/ https://www.ncbi.nlm.nih.gov/pubmed/24609110 http://dx.doi.org/10.1371/journal.pone.0087690 |
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author | Ye, Zhen Cong, Liming Ding, Gangqiang Yu, Min Zhang, Xinwei Hu, Ruying Wu, Jianjun Fang, Le Wang, Hao Zhang, Jie He, Qingfang Su, Danting Zhao, Ming Wang, Lixin Gong, Weiwei Xiao, Yuanyuan Liang, Mingbin Pan, Jin |
author_facet | Ye, Zhen Cong, Liming Ding, Gangqiang Yu, Min Zhang, Xinwei Hu, Ruying Wu, Jianjun Fang, Le Wang, Hao Zhang, Jie He, Qingfang Su, Danting Zhao, Ming Wang, Lixin Gong, Weiwei Xiao, Yuanyuan Liang, Mingbin Pan, Jin |
author_sort | Ye, Zhen |
collection | PubMed |
description | To identify optimal cut-off points of fasting plasma glucose for two-step strategy in screening of undiagnosed diabetes in Chinese people, data were selected from two cross-sectional studies of Metabolic Syndrome in Zhejiang Province of China, Zhejiang Statistical Yearbook (2010), and published literatures. Two-step strategy was used among 17437 subjects sampled from population to screen undiagnosed diabetes. Effectiveness (proportion of cases identified), costs (including medical and non-medical costs), and efficiency (cost per case identified) of these different two-step screening strategies were evaluated. This study found the sensitivities of all the two-step screening strategies with further Oral Glucose Tolerance Test (OGTT) at different Fasting Plasma Glucose (FPG) cut-off points from 5.0 to 7.0 (mmol/L) ranged from 0.66 to 0.91. For the FPG point of 5.0 mmol/L, 91 percent of undiagnosed cases were identified. The total cost of detecting one undiagnosed diabetes case ranged from 547.1 to 1294.5 CNY/case, and the strategy with FPG at cut-off point of 6.1 (mmol/L) resulted in the least cost. Considering both sensitivity and cost of screening diabetes, FPG cut-off point at 5.4 mmol/L was optimized for the two-step strategy. In conclusion, different optimal cut-off points of FPG for two-step strategy in screening of undiagnosed diabetes should be used for different screening purposes. |
format | Online Article Text |
id | pubmed-3946449 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39464492014-03-10 Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China Ye, Zhen Cong, Liming Ding, Gangqiang Yu, Min Zhang, Xinwei Hu, Ruying Wu, Jianjun Fang, Le Wang, Hao Zhang, Jie He, Qingfang Su, Danting Zhao, Ming Wang, Lixin Gong, Weiwei Xiao, Yuanyuan Liang, Mingbin Pan, Jin PLoS One Research Article To identify optimal cut-off points of fasting plasma glucose for two-step strategy in screening of undiagnosed diabetes in Chinese people, data were selected from two cross-sectional studies of Metabolic Syndrome in Zhejiang Province of China, Zhejiang Statistical Yearbook (2010), and published literatures. Two-step strategy was used among 17437 subjects sampled from population to screen undiagnosed diabetes. Effectiveness (proportion of cases identified), costs (including medical and non-medical costs), and efficiency (cost per case identified) of these different two-step screening strategies were evaluated. This study found the sensitivities of all the two-step screening strategies with further Oral Glucose Tolerance Test (OGTT) at different Fasting Plasma Glucose (FPG) cut-off points from 5.0 to 7.0 (mmol/L) ranged from 0.66 to 0.91. For the FPG point of 5.0 mmol/L, 91 percent of undiagnosed cases were identified. The total cost of detecting one undiagnosed diabetes case ranged from 547.1 to 1294.5 CNY/case, and the strategy with FPG at cut-off point of 6.1 (mmol/L) resulted in the least cost. Considering both sensitivity and cost of screening diabetes, FPG cut-off point at 5.4 mmol/L was optimized for the two-step strategy. In conclusion, different optimal cut-off points of FPG for two-step strategy in screening of undiagnosed diabetes should be used for different screening purposes. Public Library of Science 2014-03-07 /pmc/articles/PMC3946449/ /pubmed/24609110 http://dx.doi.org/10.1371/journal.pone.0087690 Text en © 2014 Ye et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Ye, Zhen Cong, Liming Ding, Gangqiang Yu, Min Zhang, Xinwei Hu, Ruying Wu, Jianjun Fang, Le Wang, Hao Zhang, Jie He, Qingfang Su, Danting Zhao, Ming Wang, Lixin Gong, Weiwei Xiao, Yuanyuan Liang, Mingbin Pan, Jin Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China |
title | Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China |
title_full | Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China |
title_fullStr | Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China |
title_full_unstemmed | Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China |
title_short | Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China |
title_sort | optimal cut-off points for two-step strategy in screening of undiagnosed diabetes: a population-based study in china |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946449/ https://www.ncbi.nlm.nih.gov/pubmed/24609110 http://dx.doi.org/10.1371/journal.pone.0087690 |
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