Activating FLT3 Mutants Show Distinct Gain-of-Function Phenotypes In Vitro and a Characteristic Signaling Pathway Profile Associated with Prognosis in Acute Myeloid Leukemia

About 30% of patients with acute myeloid leukemia (AML) harbour mutations of the receptor tyrosine kinase FLT3, mostly internal tandem duplications (ITD) and point mutations of the second tyrosine kinase domain (TKD). It was the aim of this study to comprehensively analyze clinical and functional pr...

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Detalles Bibliográficos
Autores principales: Janke, Hanna, Pastore, Friederike, Schumacher, Daniela, Herold, Tobias, Hopfner, Karl-Peter, Schneider, Stephanie, Berdel, Wolfgang E., Büchner, Thomas, Woermann, Bernhard J., Subklewe, Marion, Bohlander, Stefan K., Hiddemann, Wolfgang, Spiekermann, Karsten, Polzer, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946485/
https://www.ncbi.nlm.nih.gov/pubmed/24608088
http://dx.doi.org/10.1371/journal.pone.0089560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946485/
https://www.ncbi.nlm.nih.gov/pubmed/24608088
http://dx.doi.org/10.1371/journal.pone.0089560

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