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A comparison of functional brain changes associated with surgical versus behavioral weight loss

OBJECTIVE: Few studies have examined brain changes in response to effective weight loss; none have compared different methods of weight-loss intervention. We compared functional brain changes associated with a behavioral weight loss intervention to those associated with bariatric surgery. METHODS: 1...

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Autores principales: Bruce, Amanda S., Bruce, Jared M., Ness, Abigail R., Lepping, Rebecca J., Malley, Stephen, Hancock, Laura, Powell, Josh, Patrician, Trisha M., Breslin, Florence J., Martin, Laura E., Donnelly, Joseph E., Brooks, William M., Savage, Cary R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946492/
https://www.ncbi.nlm.nih.gov/pubmed/24115765
http://dx.doi.org/10.1002/oby.20630
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author Bruce, Amanda S.
Bruce, Jared M.
Ness, Abigail R.
Lepping, Rebecca J.
Malley, Stephen
Hancock, Laura
Powell, Josh
Patrician, Trisha M.
Breslin, Florence J.
Martin, Laura E.
Donnelly, Joseph E.
Brooks, William M.
Savage, Cary R.
author_facet Bruce, Amanda S.
Bruce, Jared M.
Ness, Abigail R.
Lepping, Rebecca J.
Malley, Stephen
Hancock, Laura
Powell, Josh
Patrician, Trisha M.
Breslin, Florence J.
Martin, Laura E.
Donnelly, Joseph E.
Brooks, William M.
Savage, Cary R.
author_sort Bruce, Amanda S.
collection PubMed
description OBJECTIVE: Few studies have examined brain changes in response to effective weight loss; none have compared different methods of weight-loss intervention. We compared functional brain changes associated with a behavioral weight loss intervention to those associated with bariatric surgery. METHODS: 15 obese participants were recruited prior to adjustable gastric banding surgery and 16 obese participants were recruited prior to a behavioral diet intervention. Groups were matched for demographics and amount of weight lost. fMRI scans (visual food motivation paradigm while hungry and following a meal) were conducted before, and 12 weeks after surgery/behavioral intervention. RESULTS: When compared to bariatric patients in the pre-meal analyses, behavioral dieters showed increased activation to food images in right medial PFC and left precuneus following weight loss. When compared to behavioral dieters, bariatric patients showed increased activation in in bilateral temporal cortex following the weight loss. CONCLUSIONS: Behavioral dieters showed increased responses to food cues in medial PFC – a region associated with valuation and processing of self-referent information – when compared to bariatric patients. Bariatric patients showed increased responses to food cues in brain regions associated with higher level perception—when compared to behavioral dieters. The method of weight loss determines unique changes in brain function.
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spelling pubmed-39464922014-08-01 A comparison of functional brain changes associated with surgical versus behavioral weight loss Bruce, Amanda S. Bruce, Jared M. Ness, Abigail R. Lepping, Rebecca J. Malley, Stephen Hancock, Laura Powell, Josh Patrician, Trisha M. Breslin, Florence J. Martin, Laura E. Donnelly, Joseph E. Brooks, William M. Savage, Cary R. Obesity (Silver Spring) Article OBJECTIVE: Few studies have examined brain changes in response to effective weight loss; none have compared different methods of weight-loss intervention. We compared functional brain changes associated with a behavioral weight loss intervention to those associated with bariatric surgery. METHODS: 15 obese participants were recruited prior to adjustable gastric banding surgery and 16 obese participants were recruited prior to a behavioral diet intervention. Groups were matched for demographics and amount of weight lost. fMRI scans (visual food motivation paradigm while hungry and following a meal) were conducted before, and 12 weeks after surgery/behavioral intervention. RESULTS: When compared to bariatric patients in the pre-meal analyses, behavioral dieters showed increased activation to food images in right medial PFC and left precuneus following weight loss. When compared to behavioral dieters, bariatric patients showed increased activation in in bilateral temporal cortex following the weight loss. CONCLUSIONS: Behavioral dieters showed increased responses to food cues in medial PFC – a region associated with valuation and processing of self-referent information – when compared to bariatric patients. Bariatric patients showed increased responses to food cues in brain regions associated with higher level perception—when compared to behavioral dieters. The method of weight loss determines unique changes in brain function. 2013-10-17 2014-02 /pmc/articles/PMC3946492/ /pubmed/24115765 http://dx.doi.org/10.1002/oby.20630 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Bruce, Amanda S.
Bruce, Jared M.
Ness, Abigail R.
Lepping, Rebecca J.
Malley, Stephen
Hancock, Laura
Powell, Josh
Patrician, Trisha M.
Breslin, Florence J.
Martin, Laura E.
Donnelly, Joseph E.
Brooks, William M.
Savage, Cary R.
A comparison of functional brain changes associated with surgical versus behavioral weight loss
title A comparison of functional brain changes associated with surgical versus behavioral weight loss
title_full A comparison of functional brain changes associated with surgical versus behavioral weight loss
title_fullStr A comparison of functional brain changes associated with surgical versus behavioral weight loss
title_full_unstemmed A comparison of functional brain changes associated with surgical versus behavioral weight loss
title_short A comparison of functional brain changes associated with surgical versus behavioral weight loss
title_sort comparison of functional brain changes associated with surgical versus behavioral weight loss
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946492/
https://www.ncbi.nlm.nih.gov/pubmed/24115765
http://dx.doi.org/10.1002/oby.20630
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