Attenuation of Hedgehog Acyltransferase-Catalyzed Sonic Hedgehog Palmitoylation Causes Reduced Signaling, Proliferation and Invasiveness of Human Carcinoma Cells

Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers. To be highly active, Hedgehog proteins must be palmitoylated at their N-terminus by the MBOAT family multispanning membrane enzyme Hedgehog acyltransferase (Hhat). In a pancreatic ductal adenocarcinoma (PDAC) ce...

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Detalles Bibliográficos
Autores principales: Konitsiotis, Antonios D., Chang, Shu-Chun, Jovanović, Biljana, Ciepla, Paulina, Masumoto, Naoko, Palmer, Christopher P., Tate, Edward W., Couchman, John R., Magee, Anthony I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946499/
https://www.ncbi.nlm.nih.gov/pubmed/24608521
http://dx.doi.org/10.1371/journal.pone.0089899

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