Impact of the Smoothened Inhibitor, IPI-926, on Smoothened Ciliary Localization and Hedgehog Pathway Activity

A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC). Activation of the Hh pathway has been implicated in a broad range of cancers, and several Smo antagonists are being assessed clinically, one...

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Detalles Bibliográficos
Autores principales: Peluso, Marisa O., Campbell, Veronica T., Harari, Joseph A., Tibbitts, Thomas T., Proctor, Jennifer L., Whitebread, Nigel, Conley, James M., White, Kerry F., Kutok, Jeffery L., Read, Margaret A., McGovern, Karen, Faia, Kerrie L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946503/
https://www.ncbi.nlm.nih.gov/pubmed/24608250
http://dx.doi.org/10.1371/journal.pone.0090534

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