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A Novel Blood-Brain Barrier Co-Culture System for Drug Targeting of Alzheimer’s Disease: Establishment by Using Acitretin as a Model Drug

In the pathogenesis of Alzheimer’s disease (AD) the homeostasis of amyloid precursor protein (APP) processing in the brain is impaired. The expression of the competing proteases ADAM10 (a disintegrin and metalloproteinase 10) and BACE-1 (beta site APP cleaving enzyme 1) is shifted in favor of the A-...

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Detalles Bibliográficos
Autores principales:	Freese, Christian, Reinhardt, Sven, Hefner, Gudrun, Unger, Ronald E., Kirkpatrick, C. James, Endres, Kristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946622/ https://www.ncbi.nlm.nih.gov/pubmed/24608847 http://dx.doi.org/10.1371/journal.pone.0091003

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