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Design Rules for Selective Binding of Nuclear Localization Signals to Minor Site of Importin α
Selectivity is a critical issue in molecular recognition. However, design rules that underlie selectivity are often not well understood. Here, we studied five classical nuclear localization signals (NLSs) that contain the motif KRx(W/F/Y)xxAF and selectively bind to the minor site of importin α. The...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946659/ https://www.ncbi.nlm.nih.gov/pubmed/24609064 http://dx.doi.org/10.1371/journal.pone.0091025 |