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Cortical Depth Dependence of the Diffusion Anisotropy in the Human Cortical Gray Matter In Vivo

Diffusion tensor imaging (DTI) is typically used to study white matter fiber pathways, but may also be valuable to assess the microstructure of cortical gray matter. Although cortical diffusion anisotropy has previously been observed in vivo, its cortical depth dependence has mostly been examined in...

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Detalles Bibliográficos
Autores principales: Truong, Trong-Kha, Guidon, Arnaud, Song, Allen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946789/
https://www.ncbi.nlm.nih.gov/pubmed/24608869
http://dx.doi.org/10.1371/journal.pone.0091424
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author Truong, Trong-Kha
Guidon, Arnaud
Song, Allen W.
author_facet Truong, Trong-Kha
Guidon, Arnaud
Song, Allen W.
author_sort Truong, Trong-Kha
collection PubMed
description Diffusion tensor imaging (DTI) is typically used to study white matter fiber pathways, but may also be valuable to assess the microstructure of cortical gray matter. Although cortical diffusion anisotropy has previously been observed in vivo, its cortical depth dependence has mostly been examined in high-resolution ex vivo studies. This study thus aims to investigate the cortical depth dependence of the diffusion anisotropy in the human cortex in vivo on a clinical 3 T scanner. Specifically, a novel multishot constant-density spiral DTI technique with inherent correction of motion-induced phase errors was used to achieve a high spatial resolution (0.625×0.625×3 mm) and high spatial fidelity with no scan time penalty. The results show: (i) a diffusion anisotropy in the cortical gray matter, with a primarily radial diffusion orientation, as observed in previous ex vivo and in vivo studies, and (ii) a cortical depth dependence of the fractional anisotropy, with consistently higher values in the middle cortical lamina than in the deep and superficial cortical laminae, as observed in previous ex vivo studies. These results, which are consistent across subjects, demonstrate the feasibility of this technique for investigating the cortical depth dependence of the diffusion anisotropy in the human cortex in vivo.
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spelling pubmed-39467892014-03-10 Cortical Depth Dependence of the Diffusion Anisotropy in the Human Cortical Gray Matter In Vivo Truong, Trong-Kha Guidon, Arnaud Song, Allen W. PLoS One Research Article Diffusion tensor imaging (DTI) is typically used to study white matter fiber pathways, but may also be valuable to assess the microstructure of cortical gray matter. Although cortical diffusion anisotropy has previously been observed in vivo, its cortical depth dependence has mostly been examined in high-resolution ex vivo studies. This study thus aims to investigate the cortical depth dependence of the diffusion anisotropy in the human cortex in vivo on a clinical 3 T scanner. Specifically, a novel multishot constant-density spiral DTI technique with inherent correction of motion-induced phase errors was used to achieve a high spatial resolution (0.625×0.625×3 mm) and high spatial fidelity with no scan time penalty. The results show: (i) a diffusion anisotropy in the cortical gray matter, with a primarily radial diffusion orientation, as observed in previous ex vivo and in vivo studies, and (ii) a cortical depth dependence of the fractional anisotropy, with consistently higher values in the middle cortical lamina than in the deep and superficial cortical laminae, as observed in previous ex vivo studies. These results, which are consistent across subjects, demonstrate the feasibility of this technique for investigating the cortical depth dependence of the diffusion anisotropy in the human cortex in vivo. Public Library of Science 2014-03-07 /pmc/articles/PMC3946789/ /pubmed/24608869 http://dx.doi.org/10.1371/journal.pone.0091424 Text en © 2014 Truong et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Truong, Trong-Kha
Guidon, Arnaud
Song, Allen W.
Cortical Depth Dependence of the Diffusion Anisotropy in the Human Cortical Gray Matter In Vivo
title Cortical Depth Dependence of the Diffusion Anisotropy in the Human Cortical Gray Matter In Vivo
title_full Cortical Depth Dependence of the Diffusion Anisotropy in the Human Cortical Gray Matter In Vivo
title_fullStr Cortical Depth Dependence of the Diffusion Anisotropy in the Human Cortical Gray Matter In Vivo
title_full_unstemmed Cortical Depth Dependence of the Diffusion Anisotropy in the Human Cortical Gray Matter In Vivo
title_short Cortical Depth Dependence of the Diffusion Anisotropy in the Human Cortical Gray Matter In Vivo
title_sort cortical depth dependence of the diffusion anisotropy in the human cortical gray matter in vivo
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946789/
https://www.ncbi.nlm.nih.gov/pubmed/24608869
http://dx.doi.org/10.1371/journal.pone.0091424
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