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Immunological and Virological Mechanisms of Vaccine-Mediated Protection Against SIV and HIV
A major challenge for the development of a highly effective AIDS vaccine is the identification of mechanisms of protective immunity. To address this question, we used a non-human primate challenge model with simian immunodeficiency virus (SIV). We show that antibodies to the SIV Envelope are necessa...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946913/ https://www.ncbi.nlm.nih.gov/pubmed/24352234 http://dx.doi.org/10.1038/nature12893 |
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author | Roederer, Mario Keele, Brandon F. Schmidt, Stephen D. Mason, Rosemarie D. Welles, Hugh C. Fischer, Will Labranche, Celia Foulds, Kathryn E. Louder, Mark K. Yang, Zhi-Yong Todd, John-Paul M. Buzby, Adam P. Mach, Linh V. Shen, Ling Seaton, Kelly E. Ward, Brandy M. Bailer, Robert T. Gottardo, Raphael Gu, Wenjuan Ferrari, Guido Alam, S. Munir Denny, Thomas N. Montefiori, David C. Tomaras, Georgia D. Korber, Bette T. Nason, Martha C. Seder, Robert A. Koup, Richard A. Letvin, Norman L. Rao, Srinivas S. Nabel, Gary J. Mascola, John R. |
author_facet | Roederer, Mario Keele, Brandon F. Schmidt, Stephen D. Mason, Rosemarie D. Welles, Hugh C. Fischer, Will Labranche, Celia Foulds, Kathryn E. Louder, Mark K. Yang, Zhi-Yong Todd, John-Paul M. Buzby, Adam P. Mach, Linh V. Shen, Ling Seaton, Kelly E. Ward, Brandy M. Bailer, Robert T. Gottardo, Raphael Gu, Wenjuan Ferrari, Guido Alam, S. Munir Denny, Thomas N. Montefiori, David C. Tomaras, Georgia D. Korber, Bette T. Nason, Martha C. Seder, Robert A. Koup, Richard A. Letvin, Norman L. Rao, Srinivas S. Nabel, Gary J. Mascola, John R. |
author_sort | Roederer, Mario |
collection | PubMed |
description | A major challenge for the development of a highly effective AIDS vaccine is the identification of mechanisms of protective immunity. To address this question, we used a non-human primate challenge model with simian immunodeficiency virus (SIV). We show that antibodies to the SIV Envelope are necessary and sufficient to prevent infection. Moreover, sequencing of viruses from breakthrough infections revealed selective pressure against neutralization-sensitive viruses; we identified a two amino acid signature that alters antigenicity and confers neutralization resistance. A similar signature confers resistance of HIV-1 to neutralization by monoclonal antibodies against variable regions 1 and 2 (V1V2), suggesting that SIV and HIV share a fundamental mechanism of immune escape from vaccine- or naturally-elicited antibodies. These analyses provide insight into the limited efficacy seen in HIV vaccine trials. |
format | Online Article Text |
id | pubmed-3946913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
record_format | MEDLINE/PubMed |
spelling | pubmed-39469132014-07-23 Immunological and Virological Mechanisms of Vaccine-Mediated Protection Against SIV and HIV Roederer, Mario Keele, Brandon F. Schmidt, Stephen D. Mason, Rosemarie D. Welles, Hugh C. Fischer, Will Labranche, Celia Foulds, Kathryn E. Louder, Mark K. Yang, Zhi-Yong Todd, John-Paul M. Buzby, Adam P. Mach, Linh V. Shen, Ling Seaton, Kelly E. Ward, Brandy M. Bailer, Robert T. Gottardo, Raphael Gu, Wenjuan Ferrari, Guido Alam, S. Munir Denny, Thomas N. Montefiori, David C. Tomaras, Georgia D. Korber, Bette T. Nason, Martha C. Seder, Robert A. Koup, Richard A. Letvin, Norman L. Rao, Srinivas S. Nabel, Gary J. Mascola, John R. Nature Article A major challenge for the development of a highly effective AIDS vaccine is the identification of mechanisms of protective immunity. To address this question, we used a non-human primate challenge model with simian immunodeficiency virus (SIV). We show that antibodies to the SIV Envelope are necessary and sufficient to prevent infection. Moreover, sequencing of viruses from breakthrough infections revealed selective pressure against neutralization-sensitive viruses; we identified a two amino acid signature that alters antigenicity and confers neutralization resistance. A similar signature confers resistance of HIV-1 to neutralization by monoclonal antibodies against variable regions 1 and 2 (V1V2), suggesting that SIV and HIV share a fundamental mechanism of immune escape from vaccine- or naturally-elicited antibodies. These analyses provide insight into the limited efficacy seen in HIV vaccine trials. 2013-12-18 2014-01-23 /pmc/articles/PMC3946913/ /pubmed/24352234 http://dx.doi.org/10.1038/nature12893 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Roederer, Mario Keele, Brandon F. Schmidt, Stephen D. Mason, Rosemarie D. Welles, Hugh C. Fischer, Will Labranche, Celia Foulds, Kathryn E. Louder, Mark K. Yang, Zhi-Yong Todd, John-Paul M. Buzby, Adam P. Mach, Linh V. Shen, Ling Seaton, Kelly E. Ward, Brandy M. Bailer, Robert T. Gottardo, Raphael Gu, Wenjuan Ferrari, Guido Alam, S. Munir Denny, Thomas N. Montefiori, David C. Tomaras, Georgia D. Korber, Bette T. Nason, Martha C. Seder, Robert A. Koup, Richard A. Letvin, Norman L. Rao, Srinivas S. Nabel, Gary J. Mascola, John R. Immunological and Virological Mechanisms of Vaccine-Mediated Protection Against SIV and HIV |
title | Immunological and Virological Mechanisms of Vaccine-Mediated Protection Against SIV and HIV |
title_full | Immunological and Virological Mechanisms of Vaccine-Mediated Protection Against SIV and HIV |
title_fullStr | Immunological and Virological Mechanisms of Vaccine-Mediated Protection Against SIV and HIV |
title_full_unstemmed | Immunological and Virological Mechanisms of Vaccine-Mediated Protection Against SIV and HIV |
title_short | Immunological and Virological Mechanisms of Vaccine-Mediated Protection Against SIV and HIV |
title_sort | immunological and virological mechanisms of vaccine-mediated protection against siv and hiv |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946913/ https://www.ncbi.nlm.nih.gov/pubmed/24352234 http://dx.doi.org/10.1038/nature12893 |
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