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Energetic analysis of the R*-G complex links the α5 helix to GDP release and domain opening
We present a model of interaction of G(i) protein with activated rhodopsin (R*) which pin-points energetic contributions to activation and reconciles the β(2)AR–G(s) crystal structure with new and previously published experimental data. In silico analysis demonstrated energetic changes when the Gα C...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947367/ https://www.ncbi.nlm.nih.gov/pubmed/24292645 http://dx.doi.org/10.1038/nsmb.2705 |