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Energetic analysis of the R*-G complex links the α5 helix to GDP release and domain opening

We present a model of interaction of G(i) protein with activated rhodopsin (R*) which pin-points energetic contributions to activation and reconciles the β(2)AR–G(s) crystal structure with new and previously published experimental data. In silico analysis demonstrated energetic changes when the Gα C...

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Detalles Bibliográficos
Autores principales:	Alexander, Nathan S., Preininger, Anita M., Kaya, Ali I., Stein, Richard A., Hamm, Heidi E., Meiler, Jens
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947367/ https://www.ncbi.nlm.nih.gov/pubmed/24292645 http://dx.doi.org/10.1038/nsmb.2705

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