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Primary Carcinoma of the Fallopian Tube: A Review of a Single Institution Experience of 8 Cases

Aims and Objectives. To evaluate the clinicopathologic features, response to cytoreductive surgery and adjuvant platinum-based chemotherapy with or without paclitaxel. Materials and Methods. A retrospective observational study of 8 women with a histopathologic diagnosis of primary fallopian tube car...

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Autores principales: Nanaiah, Shakuntala P., Rathod, Praveen S., Rajkumar, Namrata N., Kundargi, Rajshekar, Subbian, Anbukkani, Ramachandra, Pallavi V., Krishnappa, Shobha, Narayan, Abhilasha, Devi, Uma K., Uttamchand, Bafna D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947731/
https://www.ncbi.nlm.nih.gov/pubmed/24696653
http://dx.doi.org/10.1155/2014/630731
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author Nanaiah, Shakuntala P.
Rathod, Praveen S.
Rajkumar, Namrata N.
Kundargi, Rajshekar
Subbian, Anbukkani
Ramachandra, Pallavi V.
Krishnappa, Shobha
Narayan, Abhilasha
Devi, Uma K.
Uttamchand, Bafna D.
author_facet Nanaiah, Shakuntala P.
Rathod, Praveen S.
Rajkumar, Namrata N.
Kundargi, Rajshekar
Subbian, Anbukkani
Ramachandra, Pallavi V.
Krishnappa, Shobha
Narayan, Abhilasha
Devi, Uma K.
Uttamchand, Bafna D.
author_sort Nanaiah, Shakuntala P.
collection PubMed
description Aims and Objectives. To evaluate the clinicopathologic features, response to cytoreductive surgery and adjuvant platinum-based chemotherapy with or without paclitaxel. Materials and Methods. A retrospective observational study of 8 women with a histopathologic diagnosis of primary fallopian tube carcinoma (PFTC) from January 2000 to February 2013. Results. 4/8 (50%) of the women were in the early stage and an intraoperative frozen section was 100% effective in identifying fallopian tube carcinoma and then a staging laparotomy was performed. All 4/8 cases in the early stage had received and responded to single agent carboplatin and all are alive without clinical, radiological, or biochemical evidence of recurrence at the end of 2 years and the longest survivor has completed 13 years. Primary optimal cytoreductive surgery was achievable in 3/4 (75%) in advanced disease. All showed response to adjuvant paclitaxel and carboplatin (T+C), but all had succumbed to the disease following recurrence with mean progression-free survival of 19 months (range 15–21 months) and mean overall survival of 27 months (range 22–36 months). Conclusion. The pivotal role played by a frozen section in diagnosing PFTC which is rare needs to be reemphasized, therefore justifying a primary staging laparotomy in an early stage. Prolonged survival observed in this group following an optimum tailored adjuvant single agent carboplatin is worth noting.
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spelling pubmed-39477312014-04-02 Primary Carcinoma of the Fallopian Tube: A Review of a Single Institution Experience of 8 Cases Nanaiah, Shakuntala P. Rathod, Praveen S. Rajkumar, Namrata N. Kundargi, Rajshekar Subbian, Anbukkani Ramachandra, Pallavi V. Krishnappa, Shobha Narayan, Abhilasha Devi, Uma K. Uttamchand, Bafna D. ScientificWorldJournal Research Article Aims and Objectives. To evaluate the clinicopathologic features, response to cytoreductive surgery and adjuvant platinum-based chemotherapy with or without paclitaxel. Materials and Methods. A retrospective observational study of 8 women with a histopathologic diagnosis of primary fallopian tube carcinoma (PFTC) from January 2000 to February 2013. Results. 4/8 (50%) of the women were in the early stage and an intraoperative frozen section was 100% effective in identifying fallopian tube carcinoma and then a staging laparotomy was performed. All 4/8 cases in the early stage had received and responded to single agent carboplatin and all are alive without clinical, radiological, or biochemical evidence of recurrence at the end of 2 years and the longest survivor has completed 13 years. Primary optimal cytoreductive surgery was achievable in 3/4 (75%) in advanced disease. All showed response to adjuvant paclitaxel and carboplatin (T+C), but all had succumbed to the disease following recurrence with mean progression-free survival of 19 months (range 15–21 months) and mean overall survival of 27 months (range 22–36 months). Conclusion. The pivotal role played by a frozen section in diagnosing PFTC which is rare needs to be reemphasized, therefore justifying a primary staging laparotomy in an early stage. Prolonged survival observed in this group following an optimum tailored adjuvant single agent carboplatin is worth noting. Hindawi Publishing Corporation 2014-02-13 /pmc/articles/PMC3947731/ /pubmed/24696653 http://dx.doi.org/10.1155/2014/630731 Text en Copyright © 2014 Shakuntala P. Nanaiah et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nanaiah, Shakuntala P.
Rathod, Praveen S.
Rajkumar, Namrata N.
Kundargi, Rajshekar
Subbian, Anbukkani
Ramachandra, Pallavi V.
Krishnappa, Shobha
Narayan, Abhilasha
Devi, Uma K.
Uttamchand, Bafna D.
Primary Carcinoma of the Fallopian Tube: A Review of a Single Institution Experience of 8 Cases
title Primary Carcinoma of the Fallopian Tube: A Review of a Single Institution Experience of 8 Cases
title_full Primary Carcinoma of the Fallopian Tube: A Review of a Single Institution Experience of 8 Cases
title_fullStr Primary Carcinoma of the Fallopian Tube: A Review of a Single Institution Experience of 8 Cases
title_full_unstemmed Primary Carcinoma of the Fallopian Tube: A Review of a Single Institution Experience of 8 Cases
title_short Primary Carcinoma of the Fallopian Tube: A Review of a Single Institution Experience of 8 Cases
title_sort primary carcinoma of the fallopian tube: a review of a single institution experience of 8 cases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947731/
https://www.ncbi.nlm.nih.gov/pubmed/24696653
http://dx.doi.org/10.1155/2014/630731
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