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Targeting Gli Transcription Activation by Small Molecule Suppresses Tumor Growth
Targeted inhibition of Hedgehog signaling at the cell membrane has been associated with anti-cancer activity in preclinical and early clinical studies. Hedgehog signaling involves activation of Gli transcription factors that can also be induced by alternative pathways. In this study we identified an...
Autores principales: | Bosco-Clément, Geneviève, Zhang, Fang, Chen, Zhao, Zhou, Hai-Meng, Li, Hui, Mikami, Iwao, Hirata, Tomomi, Yagui-Beltran, Adam, Lui, Natalie, Do, Hanh T., Cheng, Tiffany, Tseng, Hsin-Hui, Choi, Helen, Fang, Li-Tai, Kim, Il-Jin, Yue, Dongsheng, Wang, Changli, Zheng, Qingfeng, Fujii, Naoaki, Mann, Michael, Jablons, David M., He, Biao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947751/ https://www.ncbi.nlm.nih.gov/pubmed/23686308 http://dx.doi.org/10.1038/onc.2013.164 |
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