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High Nuclear Expression of HDGF Correlates with Disease Progression and Poor Prognosis in Human Endometrial Carcinoma

Aims. This study examined the correlation between high nuclear expression of hepatoma-derived growth factor (HDGF) and clinicopathologic data in endometrial carcinoma (EC), including patient survival. Methods. One hundred and twenty-two endometrial carcinoma (EC) patients from 2002 to 2008 were revi...

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Autores principales: Wang, Lijing, Jiang, Qingping, Hua, Shengni, Zhao, Mengyang, Wu, Qiangyun, Fu, Qiaofen, Fang, Weiyi, Guo, Suiqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947826/
https://www.ncbi.nlm.nih.gov/pubmed/24692842
http://dx.doi.org/10.1155/2014/298795
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author Wang, Lijing
Jiang, Qingping
Hua, Shengni
Zhao, Mengyang
Wu, Qiangyun
Fu, Qiaofen
Fang, Weiyi
Guo, Suiqun
author_facet Wang, Lijing
Jiang, Qingping
Hua, Shengni
Zhao, Mengyang
Wu, Qiangyun
Fu, Qiaofen
Fang, Weiyi
Guo, Suiqun
author_sort Wang, Lijing
collection PubMed
description Aims. This study examined the correlation between high nuclear expression of hepatoma-derived growth factor (HDGF) and clinicopathologic data in endometrial carcinoma (EC), including patient survival. Methods. One hundred and twenty-two endometrial carcinoma (EC) patients from 2002 to 2008 were reviewed in the study. HDGF expression in tumor tissues was examined using immunohistochemistry (IHC), and its association with clinicopathological parameters was evaluated. Tumors with 80% or more nuclei staining were regarded as high expression and tumors with less than 80% nuclei staining considered as low expression. Results and Conclusions. Immunohistochemical analysis revealed that HDGF was expressed in both the nucleus and cytoplasm. High nuclear expression of HDGF was positively correlated with FIGO stage (P = 0.032), but not associated with other clinical features, such as histological grading or lymph node status. Patients with high expression of HDGF had poorer overall survival rates than those with low expression of HDGF (P = 0.001). However, multivariate analyses showed that high nuclear expression of HDGF protein was not an independent predictor of prognosis for EC patients (P = 0.111). Our results suggest that high nuclear expression of HDGF is a potential unfavorable factor for the progression and prognosis of EC.
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spelling pubmed-39478262014-04-01 High Nuclear Expression of HDGF Correlates with Disease Progression and Poor Prognosis in Human Endometrial Carcinoma Wang, Lijing Jiang, Qingping Hua, Shengni Zhao, Mengyang Wu, Qiangyun Fu, Qiaofen Fang, Weiyi Guo, Suiqun Dis Markers Research Article Aims. This study examined the correlation between high nuclear expression of hepatoma-derived growth factor (HDGF) and clinicopathologic data in endometrial carcinoma (EC), including patient survival. Methods. One hundred and twenty-two endometrial carcinoma (EC) patients from 2002 to 2008 were reviewed in the study. HDGF expression in tumor tissues was examined using immunohistochemistry (IHC), and its association with clinicopathological parameters was evaluated. Tumors with 80% or more nuclei staining were regarded as high expression and tumors with less than 80% nuclei staining considered as low expression. Results and Conclusions. Immunohistochemical analysis revealed that HDGF was expressed in both the nucleus and cytoplasm. High nuclear expression of HDGF was positively correlated with FIGO stage (P = 0.032), but not associated with other clinical features, such as histological grading or lymph node status. Patients with high expression of HDGF had poorer overall survival rates than those with low expression of HDGF (P = 0.001). However, multivariate analyses showed that high nuclear expression of HDGF protein was not an independent predictor of prognosis for EC patients (P = 0.111). Our results suggest that high nuclear expression of HDGF is a potential unfavorable factor for the progression and prognosis of EC. Hindawi Publishing Corporation 2014 2014-02-17 /pmc/articles/PMC3947826/ /pubmed/24692842 http://dx.doi.org/10.1155/2014/298795 Text en Copyright © 2014 Lijing Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Lijing
Jiang, Qingping
Hua, Shengni
Zhao, Mengyang
Wu, Qiangyun
Fu, Qiaofen
Fang, Weiyi
Guo, Suiqun
High Nuclear Expression of HDGF Correlates with Disease Progression and Poor Prognosis in Human Endometrial Carcinoma
title High Nuclear Expression of HDGF Correlates with Disease Progression and Poor Prognosis in Human Endometrial Carcinoma
title_full High Nuclear Expression of HDGF Correlates with Disease Progression and Poor Prognosis in Human Endometrial Carcinoma
title_fullStr High Nuclear Expression of HDGF Correlates with Disease Progression and Poor Prognosis in Human Endometrial Carcinoma
title_full_unstemmed High Nuclear Expression of HDGF Correlates with Disease Progression and Poor Prognosis in Human Endometrial Carcinoma
title_short High Nuclear Expression of HDGF Correlates with Disease Progression and Poor Prognosis in Human Endometrial Carcinoma
title_sort high nuclear expression of hdgf correlates with disease progression and poor prognosis in human endometrial carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947826/
https://www.ncbi.nlm.nih.gov/pubmed/24692842
http://dx.doi.org/10.1155/2014/298795
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