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Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice

Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy. It has been reported that dietary Pi regulates circulating FGF23. In thi...

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Autores principales: Nakahashi, Otoki, Yamamoto, Hironori, Tanaka, Sarasa, Kozai, Mina, Takei, Yuichiro, Masuda, Masashi, Kaneko, Ichiro, Taketani, Yutaka, Iwano, Masayuki, Miyamoto, Ken-ichi, Takeda, Eiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947966/
https://www.ncbi.nlm.nih.gov/pubmed/24688219
http://dx.doi.org/10.3164/jcbn.13-109
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author Nakahashi, Otoki
Yamamoto, Hironori
Tanaka, Sarasa
Kozai, Mina
Takei, Yuichiro
Masuda, Masashi
Kaneko, Ichiro
Taketani, Yutaka
Iwano, Masayuki
Miyamoto, Ken-ichi
Takeda, Eiji
author_facet Nakahashi, Otoki
Yamamoto, Hironori
Tanaka, Sarasa
Kozai, Mina
Takei, Yuichiro
Masuda, Masashi
Kaneko, Ichiro
Taketani, Yutaka
Iwano, Masayuki
Miyamoto, Ken-ichi
Takeda, Eiji
author_sort Nakahashi, Otoki
collection PubMed
description Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy. It has been reported that dietary Pi regulates circulating FGF23. In this study, the short-term effects of dietary Pi restriction on the expression of FGF19 subfamily members in mice were analyzed. An initial analysis confirmed plasma FGF23 levels positively correlated with the amount of dietary Pi. On the other hand, ileal Fgf15 gene expression, but not hepatic Fgf21 gene expression, was up-regulated by dietary Pi restriction. In addition, we observed the increase of plasma 1,25-dihydroxyvitamin D [1,25(OH)(2)D] levels by dietary Pi restriction, and the up-regulation of ileal Fgf15 mRNA expression by 1,25(OH)(2)D(3) and vitamin D receptor (VDR). Importantly, dietary Pi restriction-induced Fgf15 gene expression was prevented in VDR-knockout mice. Furthermore, diurnal variations of plasma triglyceride concentrations and hepatic mRNA expression of the bile acid synthesis enzyme Cyp7a1 as one of Fgf15 negative target genes was influenced by dietary Pi restriction. These results suggest that dietary Pi restriction up-regulates ileal Fgf15 gene expression through 1,25(OH)(2)D(3) and VDR, and may affect hepatic bile acid homeostasis.
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spelling pubmed-39479662014-03-31 Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice Nakahashi, Otoki Yamamoto, Hironori Tanaka, Sarasa Kozai, Mina Takei, Yuichiro Masuda, Masashi Kaneko, Ichiro Taketani, Yutaka Iwano, Masayuki Miyamoto, Ken-ichi Takeda, Eiji J Clin Biochem Nutr Original Article Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy. It has been reported that dietary Pi regulates circulating FGF23. In this study, the short-term effects of dietary Pi restriction on the expression of FGF19 subfamily members in mice were analyzed. An initial analysis confirmed plasma FGF23 levels positively correlated with the amount of dietary Pi. On the other hand, ileal Fgf15 gene expression, but not hepatic Fgf21 gene expression, was up-regulated by dietary Pi restriction. In addition, we observed the increase of plasma 1,25-dihydroxyvitamin D [1,25(OH)(2)D] levels by dietary Pi restriction, and the up-regulation of ileal Fgf15 mRNA expression by 1,25(OH)(2)D(3) and vitamin D receptor (VDR). Importantly, dietary Pi restriction-induced Fgf15 gene expression was prevented in VDR-knockout mice. Furthermore, diurnal variations of plasma triglyceride concentrations and hepatic mRNA expression of the bile acid synthesis enzyme Cyp7a1 as one of Fgf15 negative target genes was influenced by dietary Pi restriction. These results suggest that dietary Pi restriction up-regulates ileal Fgf15 gene expression through 1,25(OH)(2)D(3) and VDR, and may affect hepatic bile acid homeostasis. the Society for Free Radical Research Japan 2014-03 2014-03-01 /pmc/articles/PMC3947966/ /pubmed/24688219 http://dx.doi.org/10.3164/jcbn.13-109 Text en Copyright © 2014 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Nakahashi, Otoki
Yamamoto, Hironori
Tanaka, Sarasa
Kozai, Mina
Takei, Yuichiro
Masuda, Masashi
Kaneko, Ichiro
Taketani, Yutaka
Iwano, Masayuki
Miyamoto, Ken-ichi
Takeda, Eiji
Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice
title Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice
title_full Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice
title_fullStr Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice
title_full_unstemmed Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice
title_short Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice
title_sort short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947966/
https://www.ncbi.nlm.nih.gov/pubmed/24688219
http://dx.doi.org/10.3164/jcbn.13-109
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