Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms

The role of the histamine H3 receptor (H3R) in cerebral ischaemia/reperfusion (I/R) injury remains unknown. Here we show that H3R expression is upregulated after I/R in two mouse models. H3R antagonists and H3R knockout attenuate I/R injury, which is reversed by an H3R-selective agonist. Interesting...

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Detalles Bibliográficos
Autores principales: Yan, Haijing, Zhang, Xiangnan, Hu, Weiwei, Ma, Jing, Hou, Weiwei, Zhang, Xingzhou, Wang, Xiaofen, Gao, Jieqiong, Shen, Yao, Lv, Jianxin, Ohtsu, Hiroshi, Han, Feng, Wang, Guanghui, Chen, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948077/
https://www.ncbi.nlm.nih.gov/pubmed/24566390
http://dx.doi.org/10.1038/ncomms4334

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