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Interleukin-15 and Soluble Interleukin-15 Receptor α in Coronary Artery Disease Patients: Association with Epicardial Fat and Indices of Adipose Tissue Distribution

Interleukin-15 (IL-15) is a pro-inflammatory cytokine which signals via a specific alpha receptor subunit (IL-15Rα). Increased IL-15 level has been observed in cardiovascular patients and IL-15 immunoreactivity has been detected at vulnerable atherosclerotic plaques. Due to the association between a...

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Autores principales: Dozio, Elena, Malavazos, Alexis Elias, Vianello, Elena, Briganti, Silvia, Dogliotti, Giada, Bandera, Francesco, Giacomazzi, Francesca, Castelvecchio, Serenella, Menicanti, Lorenzo, Sigrüener, Alexander, Schmitz, Gerd, Romanelli, Massimiliano Marco Corsi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948349/
https://www.ncbi.nlm.nih.gov/pubmed/24603895
http://dx.doi.org/10.1371/journal.pone.0090960
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author Dozio, Elena
Malavazos, Alexis Elias
Vianello, Elena
Briganti, Silvia
Dogliotti, Giada
Bandera, Francesco
Giacomazzi, Francesca
Castelvecchio, Serenella
Menicanti, Lorenzo
Sigrüener, Alexander
Schmitz, Gerd
Romanelli, Massimiliano Marco Corsi
author_facet Dozio, Elena
Malavazos, Alexis Elias
Vianello, Elena
Briganti, Silvia
Dogliotti, Giada
Bandera, Francesco
Giacomazzi, Francesca
Castelvecchio, Serenella
Menicanti, Lorenzo
Sigrüener, Alexander
Schmitz, Gerd
Romanelli, Massimiliano Marco Corsi
author_sort Dozio, Elena
collection PubMed
description Interleukin-15 (IL-15) is a pro-inflammatory cytokine which signals via a specific alpha receptor subunit (IL-15Rα). Increased IL-15 level has been observed in cardiovascular patients and IL-15 immunoreactivity has been detected at vulnerable atherosclerotic plaques. Due to the association between adipose tissue distribution, inflammation and coronary artery disease (CAD), we quantified IL-15 and IL-15Rα in CAD patients with different adiposity and adipose tissue distribution and we evaluated whether epicardial adipose tissue (EAT), a visceral fat depot surrounding and infiltrating myocardium, may be a source of both molecules. IL-15 and IL-15Rα proteins were quantified by enzyme-linked immunosorbent assays. Gene expression of IL-15 and IL-15Rα in EAT depots was evaluated by one colour microarray platform. EAT thickness was measured by echocardiography. Plasmatic IL-15 and IL-15Rα levels were higher in CAD than non-CAD patients. After classification according to adipose tissue distribution, IL-15 was higher in CAD patients with increased abdominal adiposity. Increased level of IL-15Rα was observed both in CAD and non-CAD patients with increased abdominal fat. EAT was a source of IL-15 and IL-15Rα and their expression was higher in CAD patients with increased EAT thickness. In conclusion, our data suggest that circulating levels of IL-15 and IL-15Rα seem to reflect visceral distribution of adipose tissue and that EAT may be a potential source of both IL-15 and IL-15Rα. Future studies on the relationship between IL-15, visceral fat and characteristics of atherosclerotic plaques could help to better understand the complex biology of this cytokine.
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spelling pubmed-39483492014-03-13 Interleukin-15 and Soluble Interleukin-15 Receptor α in Coronary Artery Disease Patients: Association with Epicardial Fat and Indices of Adipose Tissue Distribution Dozio, Elena Malavazos, Alexis Elias Vianello, Elena Briganti, Silvia Dogliotti, Giada Bandera, Francesco Giacomazzi, Francesca Castelvecchio, Serenella Menicanti, Lorenzo Sigrüener, Alexander Schmitz, Gerd Romanelli, Massimiliano Marco Corsi PLoS One Research Article Interleukin-15 (IL-15) is a pro-inflammatory cytokine which signals via a specific alpha receptor subunit (IL-15Rα). Increased IL-15 level has been observed in cardiovascular patients and IL-15 immunoreactivity has been detected at vulnerable atherosclerotic plaques. Due to the association between adipose tissue distribution, inflammation and coronary artery disease (CAD), we quantified IL-15 and IL-15Rα in CAD patients with different adiposity and adipose tissue distribution and we evaluated whether epicardial adipose tissue (EAT), a visceral fat depot surrounding and infiltrating myocardium, may be a source of both molecules. IL-15 and IL-15Rα proteins were quantified by enzyme-linked immunosorbent assays. Gene expression of IL-15 and IL-15Rα in EAT depots was evaluated by one colour microarray platform. EAT thickness was measured by echocardiography. Plasmatic IL-15 and IL-15Rα levels were higher in CAD than non-CAD patients. After classification according to adipose tissue distribution, IL-15 was higher in CAD patients with increased abdominal adiposity. Increased level of IL-15Rα was observed both in CAD and non-CAD patients with increased abdominal fat. EAT was a source of IL-15 and IL-15Rα and their expression was higher in CAD patients with increased EAT thickness. In conclusion, our data suggest that circulating levels of IL-15 and IL-15Rα seem to reflect visceral distribution of adipose tissue and that EAT may be a potential source of both IL-15 and IL-15Rα. Future studies on the relationship between IL-15, visceral fat and characteristics of atherosclerotic plaques could help to better understand the complex biology of this cytokine. Public Library of Science 2014-03-06 /pmc/articles/PMC3948349/ /pubmed/24603895 http://dx.doi.org/10.1371/journal.pone.0090960 Text en © 2014 Dozio et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Dozio, Elena
Malavazos, Alexis Elias
Vianello, Elena
Briganti, Silvia
Dogliotti, Giada
Bandera, Francesco
Giacomazzi, Francesca
Castelvecchio, Serenella
Menicanti, Lorenzo
Sigrüener, Alexander
Schmitz, Gerd
Romanelli, Massimiliano Marco Corsi
Interleukin-15 and Soluble Interleukin-15 Receptor α in Coronary Artery Disease Patients: Association with Epicardial Fat and Indices of Adipose Tissue Distribution
title Interleukin-15 and Soluble Interleukin-15 Receptor α in Coronary Artery Disease Patients: Association with Epicardial Fat and Indices of Adipose Tissue Distribution
title_full Interleukin-15 and Soluble Interleukin-15 Receptor α in Coronary Artery Disease Patients: Association with Epicardial Fat and Indices of Adipose Tissue Distribution
title_fullStr Interleukin-15 and Soluble Interleukin-15 Receptor α in Coronary Artery Disease Patients: Association with Epicardial Fat and Indices of Adipose Tissue Distribution
title_full_unstemmed Interleukin-15 and Soluble Interleukin-15 Receptor α in Coronary Artery Disease Patients: Association with Epicardial Fat and Indices of Adipose Tissue Distribution
title_short Interleukin-15 and Soluble Interleukin-15 Receptor α in Coronary Artery Disease Patients: Association with Epicardial Fat and Indices of Adipose Tissue Distribution
title_sort interleukin-15 and soluble interleukin-15 receptor α in coronary artery disease patients: association with epicardial fat and indices of adipose tissue distribution
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948349/
https://www.ncbi.nlm.nih.gov/pubmed/24603895
http://dx.doi.org/10.1371/journal.pone.0090960
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